paromomycin
- CAS No.
- 7542-37-2
- Chemical Name:
- paromomycin
- Synonyms
- Aminosidine;R 400;Humycin;Catenulin;Aminosidin;Gabromycin;Paucimycin;Crestomycin;Amminosidin;Gabbromycin
- CBNumber:
- CB6911922
- Molecular Formula:
- C23H45N5O14
- Molecular Weight:
- 615.63
- MOL File:
- 7542-37-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/15 10:43:33
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in rats, mice (mg/kg): >1625, >2275 orally; >650, 423 s.c.; 156, 90 i.v. (Coffey) |
|---|
paromomycin Chemical Properties,Uses,Production
Description
Paromomycin is recommended for treatment of acute and chronic forms of intestinal amobiasis, as well as for treating intestinal bacteria Salmonella and Shigella. Synonyms of this drug are aminosidine, catenulin, crestomycin, hydroxymycin, monomycin, zygomycyn, and others.
Indications
The antibacterial activity and indications for using paromomycin are analogous to those of neomycin. In addition, it is recommended for treating severe and chronic forms of gastric amebiasis. Synonyms of this drug are aminosidine, catenulin, crestomycin, hydroxymycin, monomycin, zygomycyn, and others.
World Health Organization (WHO)
Paromomycin, an aminoglycoside antibiotic was introduced into medicine in 1959 for the treatment of protozoal, helminthic and bacterial infections. It has been associated, particularly when used by parenteral route, with severe adverse effects including renal damage, neuromuscular blockage and ototoxicity, possibly leading to deafness in some patients. This route of administration is now considered obsolete. However, parenteral dosage forms of paromomycin may still remain available in certain countries.
Antimicrobial activity
A fermentation product of Streptomyces rimosus var. paromomycinus,
supplied as the sulfate. The commercial product is a
mixture of the two isomeric paromomycins I and II, which are
closely related to neomycin.
The antibacterial activity is almost identical to that of neomycin.
Since it differs from neomycin in having a hydroxyl
rather than an amino group at the 6′-position it is not sensitive
to AAC(6′) modifying enzymes. It is active against
M. tuberculosis, including multidrug-resistant strains, and the
M. avium complex.
Unlike other aminoglycosides, paromomycin is active
against some protozoa, including Entamoeba histolytica,
Cryptosporidium parvum, Leishmania spp., Giardia lamblia and
Trichomonas vaginalis. It also exhibits activity against the tapeworms
Taenia saginata, Taenia solium, Diphyllobothrium latum
and Hymenolepis nana.
It closely resembles neomycin in pharmacokinetic behavior
and liability to produce deafness and intestinal malabsorption.
Clinical Use
Intestinal amebiasis (oral)
Cutaneous leishmaniasis (topical) and visceral leishmaniasis
(intramuscular)
Nitroimidazole-resistant trichomoniasis (topical)
Its antiprotozoal activity has attracted some attention, but it
has largely been superseded by more active and less toxic compounds.
Success in treating nitroimidazole-resistant trichomoniasis
with topical paromomycin has been reported. Trials in
India and East Africa of parenteral paromomycin alone, or
in combination with sodium stibogluconate, for treatment of
visceral
leishmaniasis have shown promising results.
paromomycin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | China | 35451 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | China | 11927 | 58 | Inquiry |
| Gihi Chemicals Co., Limited | +86-0571-86217390 +8618058761490 | China | 998 | 58 | Inquiry |
| QUALITY CONTROL SOLUTIONS LTD. | 13670046396 | China | 18865 | 58 | Inquiry |
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