PAROMOMYCIN SULFATE
- CAS No.
- 1263-89-4
- Chemical Name:
- PAROMOMYCIN SULFATE
- Synonyms
- PAROMOMYCIN SULPHATE;sulf;humatin;NEOMYCIN E;PAROMOMYCIN SULFATE SALT;Neomycin Sulfate EP Impurity E;O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate;fi5853;D00868;Humagel
- CBNumber:
- CB2278832
- Molecular Formula:
- C23H47N5O18S
- Molecular Weight:
- 713.71
- MOL File:
- 1263-89-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/8 14:18:51
| Melting point | 145 °C (decomp) |
|---|---|
| alpha | D25 +50.5° (c = 1.5 in water pH 6) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days. |
| form | powder |
| color | White to Off-White |
| Water Solubility | Soluble in water |
| Merck | 14,7041 |
| BRN | 5715182 |
| Stability | Hygroscopic |
| InChIKey | LJRDOKAZOAKLDU-UDXJMMFXSA-N |
| CAS DataBase Reference | 1263-89-4 |
| EPA Substance Registry System | Paromomycin sulfate (1263-89-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| Hazard Codes | Xi |
| Risk Statements | 23/24/25-36/38-39/23/24/25-61-36/37/38 |
| Safety Statements | 26-36/37-45-38-36 |
| WGK Germany | 2 |
| RTECS | WK2320000 |
| HS Code | 2941901010 |
| Toxicity | LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli) |
PAROMOMYCIN SULFATE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P9297 | Paromomycin sulfate salt ≥98% (TLC) | 1263-89-4 | 1G | ₹7350.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P9297 | Paromomycin sulfate salt ≥98% (TLC) | 1263-89-4 | 5G | ₹14418.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1496 | Paromomycin Sulfate Pharmaceutical Secondary Standard; Certified Reference Material | 1263-89-4 | 500MG | ₹9103.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P9297 | Paromomycin sulfate salt ≥98% (TLC) | 1263-89-4 | 25G | ₹49459.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P8692 | Paromomycin sulfate salt suitable for plant cell culture, BioReagent | 1263-89-4 | 5G | ₹18034.45 | 2022-06-14 | Buy |
PAROMOMYCIN SULFATE Chemical Properties,Uses,Production
Description
Paromomycin was found in the culture broth of Streptomyces rimosus forma paromomycinus by Parke Davis & Co. in 1959. In the same year it was found in the culture broth of S. Crestomyceticus by Farmitalia and named amminosidin. Paromomycin is related structurally to neomycin, but it has a hydroxyl group at the 6 position, whereas neomycin has an amino group. Its antibacterial activity is weaker than that of neomycin, but its toxicity is much less. Paromomycin is used by intramuscular injection for therapy of respiratory, urinary, and surgical infections and by oral administration to treat dysentery and salmonellosis.
Chemical Properties
PAROMOMYCIN SULFATE is White to Off-White Solid
Uses
PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.
Definition
ChEBI: An aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoa infections. It is also used as a therapeutic against visceral leishmaniasis.
General Description
Chemical structure: aminoglycoside
Clinical Use
The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.
Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.
Safety Profile
Poison by intravenous,subcutaneous, and intramuscular routes. Mildly toxic byingestion. Mutation data reported. When heated to decomposition it emits very toxic fumesof SOx and NOx.
Purification Methods
Purify it by dissolving it in H2O (0.5g/10mL) and adding excess EtOH, filter or collect and wash with EtOH, then Et2O by centrifugation, and dry it in vacuo. An aqueous solution is stable at 37o for a week but longer at 0-5o. The free base [7542-37-2] is a white amorphous powder which should be stored under N2 because it is strongly basic and can absorb CO2 from the atmosphere. It is soluble in MeOH (less soluble in EtOH) and has [] D 25 +65o (c 1.5, MeOH). It is an antimicrobial against Gram +ve and Gram –ve bacteria and is antiamoebic. It inhibits initiation and peptide elongation during protein synthesis. [Haskell et al. J Am Chem Soc 8 1 , 3480, 3482 1959, Hichens & Rinehart J Am Chem Soc 85 1547 1963, Beilstein 18 III/IV 7534.]
PAROMOMYCIN SULFATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Biopharmacule Speciality Chemicals P Ltd (India) | +91 40 6462 1866 | Hyderabad, India | 526 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
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