Ebrotidine
- CAS No.
- 100981-43-9
- Chemical Name:
- Ebrotidine
- Synonyms
- FI3542;Ulsanic;FI-3542;FI 3542;Ebrotidine;FI 3542; ULSANIC; FI-3542; FI3542;Ebrotidine,FI 3542,Histamine Receptor,inhibit,Inhibitor,FI-3542;(E)-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide;N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide;Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-
- CBNumber:
- CB71074199
- Molecular Formula:
- C14H17BrN6O2S3
- Molecular Weight:
- 477.42
- MOL File:
- 100981-43-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:30:58
| Melting point | 142.5-146℃ |
|---|---|
| Boiling point | 633.0±65.0 °C(Predicted) |
| Density | 1.73±0.1 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 5.25±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Light Sensitive |
Ebrotidine Chemical Properties,Uses,Production
Description
Ebrocit was launched in Spain as a gastroprotective agent. It was prepared from 4-bromobenzenesulfonamide in two steps. Ebrocit's activity arises from its ability to antagonize histamine H2-receptors (the first of a new generation) showing 1.5-2.5 times higher affinity than Ranitidine and 2-fold greater affinity than cimetidine which correlates to an antisecretory potency of 1 times and 4-10 times respectively. Cytoand gastroprotection arises from increased gastric mucus production, enhanced physiochemical properties (decreased permeability of H+), and an increase in mucin glycosylation and sulfation. It acts on gastric mucosal EGF and PDGF receptor expression. Nitric oxide was also found to be involved. Ebrocit caused enhanced mucosal blood flow with anti H.pylori activity. It has diminished P450 binding which eliminates the possibility of mutagenic nitrosoamine formation.
Uses
Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.
Ebrotidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | China | 988 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Mainchem Co., Ltd. | +86-86-05926210733 +8618030271905 | China | 6572 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Shanghai Weiwei Biological Technology Co., Ltd. | 021-55669583 18616258598 | CHINA | 4398 | 58 | Inquiry |
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