Apigenin-D5
- CAS No.
- 263711-74-6
- Chemical Name:
- Apigenin-D5
- Synonyms
- Apigenin-D5;Apigenin-d5 (Major);Pelargidenon 1449-d5;[3,6,8,35d5]-Apigenin;4',5,7-Trihydroxyflavone-d5;5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d5;4H-1-Benzopyran-4-one-3,6,8-d3, 5,7-dihydroxy-2-(4-hydroxyphenyl-3,5-d2)-;3,6,8-trideuterio-2-(3,5-dideuterio-4-hydroxyphenyl)-5,7-dihydroxychromen-4-one
- CBNumber:
- CB71121213
- Molecular Formula:
- C15H5D5O5
- Molecular Weight:
- 0
- MOL File:
- 263711-74-6.mol
- Modify Date:
- 2023/6/8 9:03:09
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Apigenin-D5 Chemical Properties,Uses,Production
Description
Apigenin-d5 is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 μM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 μM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells. Apigenin, at 5 μM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.
Chemical Properties
Pale Yellow Crystalline Solid
Uses
The labelled aglucon of apiin and of apigenin-7-glucoside
Apigenin-D5 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10978 | 58 | Inquiry |
| Shandong Mopai Biotechnology Co., Ltd | 13053322091 13053322091 | China | 11056 | 58 | Inquiry |
| guoyungurui | 18162595016 | China | 9978 | 58 | Inquiry |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | China | 11289 | 58 | Inquiry |
| United States Biological | 800.520.3011 or 781.639.5092 | United States | 6256 | 80 | Inquiry |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | China | 7980 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8739 | 58 | Inquiry |