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FORTIMICIN

CAS No.: 55779-06-1

Chemical Name:: FORTIMICIN

Synonyms: kw-1070;XK-70-1;Astricin;astromicin;FORTIMYCIN;FORTIMICIN;ASTROMYCIN;fortimicina;Fortimycin A;antibiotickw-1070

CBNumber:: CB7116881

Molecular Formula:: C17H35N5O6

Molecular Weight:: 405.49

MOL File:: 55779-06-1.mol

MSDS File:: SDS

Modify Date:: 2022/12/21 16:56:50

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FORTIMICIN Properties

Melting point	>200° (dec)
alpha	D25 +87.5° (c = 0.1 in water)
Boiling point	526.82°C (rough estimate)
Density	1.0897 (rough estimate)
refractive index	1.7600 (estimate)
pka	13.16±0.70(Predicted)

SAFETY

Risk and Safety Statements

Toxicity	LD50 (of the sulfate salt) in mice (mg/kg): 380 i.v.; 400 s.c. (Nara, 1977)

FORTIMICIN Chemical Properties,Uses,Production

Definition

ChEBI: An amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at posi ion 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is adm nistered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms.

Antimicrobial activity

A pseudodisaccharide aminoglycoside produced by Micromonospora olivoasterospora. Formulated as the sulfate. Intrinsic activity is similar to that of amikacin for most groups of organisms, but activity against Ps. aeruginosa is relatively poor. It is resistant to many aminoglycoside-modifying enzymes, but is sensitive to AAC(3) and the APH(2″)/AAC(6′) bifunctional enzyme.
Peak concentrations of 10–12 mg/L were found in the blood following 200 mg intravenous or intramuscular administration to volunteers. The plasma half-life was 1.5–2 h. Over 85% of the drug was recovered in urine during the 8 h following administration.
Toxicity and side effects are similar to those observed with other aminoglycosides. Where the drug is available it is used instead of amikacin in the treatment of infections caused by susceptible organisms.

FORTIMICIN Preparation Products And Raw materials

Raw materials

Calcium carbonate SOYBEAN MEAL Peptone Celite DOWEX 50WX4-200R ION-EXCHANGE RESIN

LEAD PHOSPHITE, DIBASIC CORN STEEP LIQUOR AMBERLITE D-Glucose monohydrate Yeast extract

Potassium phosphate tribasic Starch Magnesium sulfate heptahydrate Potassium chloride

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Preparation Products

FORTIMICIN Suppliers

Global( 24)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	9030	58	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49739	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-19164747840 +86-13119157289	China	2969	58	Inquiry
BOC Sciences	1-631-485-4226; 16314854226	United States	14059	65	Inquiry
Zhejiang Huida Biotech Co., LTD	0571-0571-89903882 15990081639	China	3705	58	Inquiry
Amatek Scientific Co. Ltd.	0512-56316828	China	28819	58	Inquiry
Zhejiang Huida Biotech Co., LTD	0571-89903882 13626641628	China	3656	58	Inquiry
Sequoia Research Products Ltd.	44 7802 291086	United Kingdom	3115	69	Inquiry
AK Scientific, Inc.	650 494 8666	United States	6357	65	Inquiry

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
BOC Sciences	65
Zhejiang Huida Biotech Co., LTD	58
Amatek Scientific Co. Ltd.	58
Zhejiang Huida Biotech Co., LTD	58
Sequoia Research Products Ltd.	69
AK Scientific, Inc.	65

55779-06-1(FORTIMICIN)Related Search:

CIS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE FORTIMICIN 1,4-CYCLOHEXANEDIAMINE CIS-1,4-CYCLOHEXANEDIAMINE N,N-Dimethylcyclohexane-1,4-diamine

D-LYXOSE L-(-)-CHIRO-INOSITOL 2-deoxyfortimycin B 3-O-demethylfortimicin A ASTROMICIN SULFATE

Fortimicin KG3 Fortimicin C fortimicin B 4-N-(4-aminobenzenesulfonyl)fortimicin B FORTIMICIN AO

N-formimidoyl fortimicin A synthase Fortimicin AI Fortimicin KR

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4,6,7-pentadeoxy-beta-l-lyxo-heptopyranosyl)-6-o-methyl-mino-3 antibiotickw-1070 4-Amino-1-[(aminoacetyl)methylamino]-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol XK-70-1 ASTROMICIN SULPHATE FORTIMICIN FORTIMYCIN Abbott-44747：XK-70-1 astromicin fortimicina kw-1070 l-chiro-inositol,4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-o-(2,6-dia L-chiro-Inositol, 4-amino-1-[(aminoacetyl)methylamino]-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl- Fortimycin A 4-Amino-1-(2-amino-N-methylacetamido)-1，4-dideoxy-3-O-(2，6-diamino-2，3，4，6，7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-L-ehiroinositol ASTROMYCIN L-chiro-Inositol, 4-amino-1-[(2-aminoacetyl)methylamino]-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl- FORTIMICIN USP/EP/BP Astricin 55779-06-1 C17H35N5O6