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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Structure
CAS No.
461432-23-5
Chemical Name:
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
Synonyms
4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene;Dapagliflozin Bromo impurity;Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]-;Dapagliflozin-13;Dapaglifozin DAP Bromo;5-broMo-2-chloro-4’Dapagliflozin Impurity 15;4-(Dibenzofuranyl)boronic;Dapagliflozin Impurity 82;Dapagliflozin Intermediate 1
CBNumber:
CB71456759
Molecular Formula:
C15H14BrClO
Molecular Weight:
325.63
MOL File:
461432-23-5.mol
Modify Date:
2024/8/21 22:41:43
Request For Quotation

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Properties

Boiling point 393.0±32.0 °C(Predicted)
Density 1.371±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form Low-Melting Solid
color White to Off-White
Stability Stable under recommended storage conditions., Stable Under Recommended Storage C
InChI InChI=1S/C15H14BrClO/c1-2-18-14-6-3-11(4-7-14)9-12-10-13(16)5-8-15(12)17/h3-8,10H,2,9H2,1H3
InChIKey ZUNCHZBITMUSRD-UHFFFAOYSA-N
SMILES C1(Cl)=CC=C(Br)C=C1CC1=CC=C(OCC)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  2909309090

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Chemical Properties,Uses,Production

Uses

5-Bromo-2-chloro-4'-ethoxydiphenylmethane is a hydrocarbon derivative and can be used as an intermediate for dapagliflozin.

Synthesis

Oxalyl chloride (0.8 mL) was added to a solution of 5-bromo-2-chlorobenzoic acid (2 g) in dichloromethane (20 mL) and dimethylformamide (0.2 mL) under a nitrogen atmosphere. The reaction mixture was stirred for one hour at 25° C to 30° C. After completion of the reaction, the reaction mixture was concentrated under a vacuum at 40° C to 45° C. to obtain an oily residue. The oily residue was dissolved in dichloromethane (20 mL) and cooled to 0° C. To this solution, phenol (1.1 mL) and aluminium chloride (2.3 g) were added at 0° C. to 5° C. The reaction mixture was stirred at 0° C to 5° C for 2 hours. The reaction mixture was allowed to warm to about 20° C, and triethylsilane (3.4 mL) was slowly added to it at the same temperature. The reaction mixture was stirred for about 36 hours from 20° C to 25° C. After completion of the reaction, 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene was obtained by further purification.

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Preparation Products And Raw materials

Raw materials

Preparation Products

(2S,3R,4S,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol Bexagliflozin 4-(5-broMo-2-chlorobenzyl)phenol

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Suppliers

Global( 546)Suppliers
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TAGOOR LABORATORIES PVT LTD +919700187008 AndhraPradesh, India 93 58 Inquiry
visachem pvt ltd +91-919550300259 +91-9704672724 Telangana, India 65 58 Inquiry
EPOCH LABS +91-7702174901 +91-9515109812 Hyderabad, India 68 58 Inquiry
HEMA PHARMACEUTICALS PVT LTD +91-9537936912 +91-9537936912 Gujarat, India 48 58 Inquiry
Dynarx Technology India Limited +91-9960099480 +91-9960099480 Bangalore, India 71 58 Inquiry
Litha Life Sciences Pvt Limited +91-9849999500 +91-9849999500 Hyderabad, India 29 58 Inquiry
Vijayasri Organics Private Limited +91-9848990113 +91-9848990113 Telangana, India 43 58 Inquiry
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Chemicea Pharmaceuticals Pvt Ltd +91-918482849343 +91-8482849343 Mumbai, India 461 58 Inquiry
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TAGOOR LABORATORIES PVT LTD 58
visachem pvt ltd 58
EPOCH LABS 58
HEMA PHARMACEUTICALS PVT LTD 58
Dynarx Technology India Limited 58
Litha Life Sciences Pvt Limited 58
Vijayasri Organics Private Limited 58
ANUPAM RASAYAN INDIA LTD. 58
BNR LABORATORIES 58
Chemicea Pharmaceuticals Pvt Ltd 58

461432-23-5(4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene)Related Search:

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 4-(5-broMo-2-chlorobenzyl)phenol 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
Empagliflozin Canagliflozin heMihydrate PF-04971729 Ipragliflozin Canagliflozin
2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Donepezil 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 5-Bromo-2-chlorobenzoic acid (5-broMo-2-chlorophenyl)(2-ethoxyphenyl)Methanone
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 4-BROMO-1-CHLORO-2-ETHYLBENZENE 5-bromo-2-chloro-4’-ethoxydiphenylmethane
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5-bromo-2-chloro-4’-ethoxydiphenylmethane 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether Dapagliflozin Intermediate 1 4-broMo-1-chloro-2-[(4-ethoxyphenyl)Methyl]- 2-(4-Methoxybenzyl)-4-broMo-1-chlorobenzene 1-(5-broMo-2-chlorobenzyl)-4-ethoxybenzene 5-broMo-2-chloro-4&rsquo Dapagliflozin Intermediate II Dapagliflozin Intermediate 2 5-bromo-2-chloro-4'-ethoxydiphenylmethane###461432-23-5 (5-bromo-2-chlorobenzyl)-4-ethoxybenzene 4-(5-Brom-2-chlorbenzyl)phenyl-ethylether Dapagliflozin Impurity 15 Dapagliflozin-13 4-(Dibenzofuranyl)boronic 4-(5-Bromo-2-chlorobenzy)phenylethyl ester Dapagliflozin Impurity 82 4-Bromo-1-chloro-2-(4-ethoxybenzyl) Dapagliflozin Despyranose Bromo Impurity 4-Brom-1-chlor-2-(4-ethoxybenzyl)benzol 5-bromo-2-chloro-4’-ethoxydiphenylmethane ISO 9001：2015 REACH 4-(3-((1-ethoxyethoxy)methyl)-4-bromophenoxy)benzonitrile Supply 5-bromo-2-chloro-4'-ethoxydiphenylmethane Dapaglifozin DAP Bromo 5-bromo-2-chloro-4-ethoxydiphenylmethaneQ: What is 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the CAS Number of 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the storage condition of 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What are the applications of 5-bromo-2-chloro-4-ethoxydiphenylmethane Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]- Dapagliflozin Bromo impurity 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene Dapagliflozin Intermediate/ 5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane 4-(5- bromo -2- chlorobenzyl) phenethyl ether 5-Bromo-2-chIoro-4’-ethoxydiphenyImethane 4-Bromo-1-ChIoro 2-4-EthoxybenzyI-Benzene 4-bromo-l-chloro-2-(4-ethoxybenzyl)benzene 2-(4-ethoxybenzyl)-4-bromo-1-chloro benzene 5-bromo-2-chloro-4’-ethoxydiphenylmethane, Or 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether (5-Bromo-2-chlorobenzyl)phenyl ethyl ether 5-bromo-2-chloro-4'-ethoxydiphenylmethane 6-bromo-2-chloro-4’-ethoxydiphenylmethane 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene 461432-23-5 61432-23-5 100134-06-9 9461432-23-5 C15H14BrClO Halides Phenyls & Phenyl-Het 461432-23-5 ADVANCED INT.