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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Structure
CAS No.
189028-95-3
Chemical Name:
(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE
Synonyms
(4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one;ZT-5;idin-2-one;Ezetimibe-003;Ezetimibe INT A;(S)-3-((S)-5-(4-FL;-5-(4-Fluorophenyl);-5-hydroxypentanoyl);)-5-hydroxypentanoyL;Ezetimibe Impurity 45
CBNumber:
CB71473325
Molecular Formula:
C20H20FNO4
Molecular Weight:
357.38
MOL File:
189028-95-3.mol
MSDS File:
SDS
Modify Date:
2024/4/18 11:29:28
Request For Quotation

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Properties

Boiling point 572.7±50.0 °C(Predicted)
Density 1.297
storage temp. 2-8°C
solubility Chloroform (Sparingly), Methanol (Slightly)
form Solid
pka 14.17±0.20(Predicted)
color White to Off-White

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Chemical Properties,Uses,Production

Description

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1, 3-OXAZOLIDIN-2-ONE is a derivative of 2-oxazolidine, which is an effective antimicrobial. It can be used as a pharmaceutical intermediate for the preparation of ezetimibe which is a drug used to lower the patients’ plasma cholesterol levels.

Chemical Properties

Solid

Uses

3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one is an intermediate of Ezetimibe (E975000, E975002), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

References

http://www.cphi-online.com/ezetimibe-intermediate-4s3-prod587443.html
https://en.wikipedia.org/wiki/2-Oxazolidone

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE Suppliers

Global( 288)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Saptagir Laboratories PVT.LTD. +91-9059978049 +91-9059978049 Telangana, India 31 58 Inquiry
Varanous Labs Pvt Ltd +91-7036248882 +91-7036248882 Hyderabad, India 1541 58 Inquiry
Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd) +91-8924236065 +91-9951616502 AndhraPradesh, India 48 58 Inquiry
Scinva Chemicals and Pharmaceuticals Pvt Ltd +91-7406196725 +91-7406196725 Karnataka, India 71 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SyncoZymes (Shanghai) Co., Ltd., +86-021-68187180-811 +86-13681683526 China 188 58 Inquiry
Supplier Advantage
Saptagir Laboratories PVT.LTD. 58
Varanous Labs Pvt Ltd 58
Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd) 58
Scinva Chemicals and Pharmaceuticals Pvt Ltd 58
Pharma Affiliates 58
SynZeal Research Pvt Ltd 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SyncoZymes (Shanghai) Co., Ltd., 58

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(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE (4S)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxo-pentyl]-4-phenyl-2-Oxazolidinone EzetiMibe InterMediates 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)- 2-Oxazolidinone Ezetimibe INT A ZT-5 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl- (4S)-3-[(5R)-5-(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-pheny-1,3-oxzolidin-2-One 2-Oxazolidinone, 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4S)- -5-(4-Fluorophenyl) -5-hydroxypentanoyl) (S)-3-[(S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-2-oxazolidinone Ezetimibe Impurity 45 Ezetimibe-003 Ezetimibe Impurity 51 3-[5-(4-fluoro- phenyl)-5-hydroxy- pentanoyl]-5-phenyl- oxazolidin-2-one 3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one (S)-3-((S)-5-(4-FL idin-2-one )-5-hydroxypentanoyL (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONEENYL-2-OXAZOLIDINONE (4S)-3-[(5S)-5-(3-fluorophenyl)-5- hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL... (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one Ezetimibe Impuriry 51 Ezetimibe intermediate D 189028-95-3 (4S)-3-[(5S)-5-(3-FLUOROPHENYL)-5- 3-[(5S)-5-(4-Fluorophenyl)-5-hydroxy-1-oxopentyl]-4(S)-phenyl-2-oxazolidinone (4S) -3- [(5S) -5- (4-fluorophenyl) -5-hydroxyvaleryl] -4-phenyl-1,3-oxyazacyclopentane-2-one 189028-95-3 Ezetimibe Ezetimibe intermediates 189028-95-3