5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- CAS No.
- 881674-56-2
- Chemical Name:
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- Synonyms
- 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde;Vonorazan;VONOPRAZAN IST-1;5-(2-FL;e-3-carbaL;)-1H-pyrroL;Vonoprazan-1;Vonoprazan-023
- CBNumber:
- CB52638918
- Molecular Formula:
- C11H8FNO
- Molecular Weight:
- 189.19
- MOL File:
- 881674-56-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/26 14:55:36
| Melting point | 133 °C |
|---|---|
| Boiling point | 370.6±32.0 °C(Predicted) |
| Density | 1.270±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.77±0.50(Predicted) |
| color | Light Brown to Brown |
| Stability | Hygroscopic |
| InChI | InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H |
| InChIKey | MQULPEUCGKEHEG-UHFFFAOYSA-N |
| SMILES | N1C(C2=CC=CC=C2F)=CC(C=O)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312-P362+P364 |
| HS Code | 2933998090 |
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | F1074 | 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde min. 98.0 % | 881674-56-2 | 1G | ₹7600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F1074 | 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde min. 98.0 % | 881674-56-2 | 5G | ₹17500 | 2022-05-26 | Buy |
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties,Uses,Production
Description
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is an ether. It can be used to prepare vonoprazan fumarate, which is a potent orally active potassium-competitive acid blocker (P-CAB) with antisecretory activity. It is used in the study of acid-related diseases.
Chemical Properties
Light orange to Yellow to Green powder to crystal.
Uses
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
Application
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
Preparation
Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.
Definition
The 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde is an important intermediate of Voranolan fumarate, a competitive potassium ion acid blocker. Voranolan fumarate treats gastric ulcers, duodenal ulcers, reflux esophagitis, etc. 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde can be synthesized in one pot using 2-(2-fluorobenzoyl)malononitrile as raw material.
Hazard
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde has acute toxin effects and is a skin and eye irritant.
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Veer Pharmachem | +91-02645661117 +91-9879471589 | Gujarat, India | 39 | 58 | Inquiry |
| SYNARTIS PHARMA PVT LTD | +919949688280 | Hyderabad, India | 92 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| SHOBHA LIFE SCIENCES PRIVATE LIMITED | +919121212469 | Hyderabad, India | 31 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Stereokem Pvt Ltd | +91-4029706929 +91-9394224843 | Telangana, India | 350 | 58 | Inquiry |
| sgtlifesciences | +91-9866957562 +91-9866957562 | Telangana, India | 90 | 58 | Inquiry |
| Mekanar Pharma Private Limited | +91-9154988357 +91-9948050784 | Hyderabad, India | 26 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
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