ChemicalBook > Product Catalog >Organic Chemistry >Ketones >7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- CAS No.
- 73942-87-7
- Chemical Name:
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- Synonyms
- 8-Dimethoxy-1;Ivabradine Impurity 13;Ivabradine Impurity 73;Ivabradine Impurity 22;3-dihydro-2H-3-benzazepin-2-one;7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one;7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one;7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one>1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
- CBNumber:
- CB71503994
- Molecular Formula:
- C12H13NO3
- Molecular Weight:
- 219.24
- MOL File:
- 73942-87-7.mol
- Modify Date:
- 2023/12/18 16:59:08
| Melting point | 244.0 to 248.0 °C |
|---|---|
| Boiling point | 455.8±45.0 °C(Predicted) |
| Density | 1.167 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 13.29±0.20(Predicted) |
| color | Off-White to Pale Beige |
| LogP | 1.23 at 23℃ and pH6.47 |
| Surface tension | 71mN/m at 36.9mg/L and 19℃ |
| CAS DataBase Reference | 73942-87-7(CAS DataBase Reference) |
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | D4824 | 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one min. 98.0 % | 73942-87-7 | 1G | ₹4900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4824 | 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one min. 98.0 % | 73942-87-7 | 5G | ₹13400 | 2022-05-26 | Buy |
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties,Uses,Production
Uses
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.
Application
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.
Synthesis
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 311)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| TAGOOR LABORATORIES PVT LTD | +919700187008 | AndhraPradesh, India | 93 | 58 | Inquiry |
| Urantiis Pharmaceuticals Private Limited | +918790703567 | AndhraPradesh, India | 80 | 58 | Inquiry |
| Rampex Labs Private Limited | +91 9168074433 | Telangana, India | 71 | 58 | Inquiry |
| Molkem Chemicals | +91-917228022464 +91-7228022464 | Ahmedabad, India | 138 | 58 | Inquiry |
| Lorven therapeutics Pvt Ltd | +91-8884110005 +91-8884110005 | Hyderabad, India | 110 | 58 | Inquiry |
| Greenovel life sciences Pvt Ltd | Hyderabad, India | 138 | 58 | Inquiry | |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Alcove International | +91-9998996552 +91-9998996552 | Gujarat, India | 24 | 58 | Inquiry |
| Glenfin Chemicals Pvt Ltd | +91-9923430013 +91-9323802458 | Maharashtra, India | 63 | 58 | Inquiry |
73942-87-7(7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one)Related Search:
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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one CAS 73942-87-7
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