4,5-Dimethoxy-1-cyanobenzocyclobutane

CAS No.: 35202-54-1

Chemical Name:: 4,5-Dimethoxy-1-cyanobenzocyclobutane

Synonyms: 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile;4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carbonitrile;3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile;NSC 154410;Ivabradine Impurity 79;Ivabradine Impurity 89;5-Dimethoxy-1-cyanobenzocyclobutane;1-Cyano-4,5-dimethoxybenzocyclobutene;4,5-Dimethoxy-1-cyanobenzocyclobutane;4,5-Dimethoxy-1-benzocyclobutenecarbonitrile>

CBNumber:: CB01503975

Molecular Formula:: C11H11NO2

Molecular Weight:: 189.21

MOL File:: 35202-54-1.mol

Modify Date:: 2024/8/17 21:30:02

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4,5-Dimethoxy-1-cyanobenzocyclobutane Properties

Melting point	83-84 °C
Boiling point	345.9±42.0 °C(Predicted)
Density	1.18
vapor pressure	0.004Pa at 25℃
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO, Methanol
form	Solid
color	Light Brown
LogP	1.22 at 30℃ and pH7
CAS DataBase Reference	35202-54-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319

Precautionary statements

P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312

HS Code

2926907090

NFPA 704

	0
2		0

4,5-Dimethoxy-1-cyanobenzocyclobutane price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	D4485	4,5-Dimethoxy-1-benzocyclobutenecarbonitrile	35202-54-1	1G	₹6600	2022-05-26	Buy
TCI Chemicals (India)	D4485	4,5-Dimethoxy-1-benzocyclobutenecarbonitrile	35202-54-1	5G	₹27700	2022-05-26	Buy

Product number	Packaging	Price	Buy
D4485	1G	₹6600	Buy
D4485	5G	₹27700	Buy

4,5-Dimethoxy-1-cyanobenzocyclobutane Chemical Properties,Uses,Production

Uses

4,5-Dimethoxy-1-cyanobenzocyclobutane is used in the preparation of selective bradycardic agents.

Synthesis

NaNH2 (39.0 g, 1.0 mol) was added in portions to a solution of hydrocinnamonitrile 8 (224.0 g, 0.83 mol) in liquid ammonia at -45°C, and the reaction mixture was stirred at -45 °C for 2 h. After evaporation of the excess NH3, NH4Cl (20.0 g) and water (1000 mL) were added in portions. After standing at room temperature, greyish crystals separated and were collected and recrystallised with ethanol to give 4,5-Dimethoxy-1-cyanobenzocyclobutane as a colourless powder. Yield 116.5 g (74%).

4,5-Dimethoxy-1-cyanobenzocyclobutane Preparation Products And Raw materials

Raw materials

(E)-3-(3,4-dimethoxyphenyl)acrylonitrile 3-(3,4-Dimethoxyphenyl)propanenitrile 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-one 3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE 4,5-dimethoxy-2-methylbenzaldehyde

4,5-DIBROMOVERATROLE 2-Bromo-4,5-Dimethoxybenzyl Bromide 4-Bromoveratrole 3,4-Dimethoxybenzyl alcohol Veratraldehyde

1,2-Dimethoxybenzene

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Preparation Products

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE

4,5-Dimethoxy-1-cyanobenzocyclobutane Suppliers

Global( 262)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TAGOOR LABORATORIES PVT LTD	+919700187008	AndhraPradesh, India	93	58	Inquiry
Greenovel life sciences Pvt Ltd		Hyderabad, India	138	58	Inquiry
Aventus Labs	+91-7021872517 +91-9324342304	Maharashtra, India	168	58	Inquiry
Pharmaffiliates Analytics & Synthetics (P) Ltd.	91-172-5066494	Haryana, India	631	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Santo Righello Pvt. Ltd	91-9885571757	Hyderabad, India	919	58	Inquiry
Trignokem International	+91-40-2374 0789	Andhra Pradesh, India	110	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
NIFTY LABS PVT. LTD	+91-40-66464099	New Delhi, India	38	58	Inquiry
Blue Waters International	91-9820281124	Mumbai, India	87	58	Inquiry

Supplier	Advantage
TAGOOR LABORATORIES PVT LTD	58
Greenovel life sciences Pvt Ltd	58
Aventus Labs	58
Pharmaffiliates Analytics & Synthetics (P) Ltd.	58
SynZeal Research Pvt Ltd	58
Santo Righello Pvt. Ltd	58
Trignokem International	58
TCI Chemicals (India) Pvt. Ltd.	58
NIFTY LABS PVT. LTD	58
Blue Waters International	58

35202-54-1(4,5-Dimethoxy-1-cyanobenzocyclobutane)Related Search:

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(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one 4-Hydroxypiperidine 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate Ethyl (3R)-piperidine-3-carboxylate

Ivabradine Impurity 70 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 1204612-29-2 3,4-dimethoxy-N-methylbenzamide 8-DeMethyl Ivabradine

N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide Hydroxy Ivabradine (3,4-Dimethoxyphenyl)acetic acid

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4,5-Dimethoxy-1-cyanobenzocyclobutane Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile,3,4-diMethoxy- 4,5-DiMethxoy-1,2-dihydrocyclobutabenzene-1-carbonitrile 2-cyclobutyl-2-(3,4-diMethoxyphenyl)acetonitrile 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-8-carbonitrile 1,2-Dihydro-4,5-diMethoxybenzocyclobutene-1-carbonitrile NSC 154410 1-Cyano-4,5-dimethoxybenzocyclobutene 4,5-diMethoxy-1-cyanobenzocyclobutane (For Ivabradine) 4,5-Dimethoxy-1-cyanobenzocyclobutane CAS 35202-54-1 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile> 5-Dimethoxy-1-cyanobenzocyclobutane Ivabradine Impurity 79 3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile 4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carbonitrile Ivabradine Impurity 89 35202-54-1