1,2-Dimethoxybenzene
- CAS No.
- 91-16-7
- Chemical Name:
- 1,2-Dimethoxybenzene
- Synonyms
- VERATROLE;Benzene, 1,2-dimethoxy-;VERATROL;Veretrole;ODMB;Synthol;O-DIMETHOXYBENZENE;1,2-Dimethoxybenzol;GUAIACOL METHYL ETHER;CATECHOL DIMETHYL ETHER
- CBNumber:
- CB5144392
- Molecular Formula:
- C8H10O2
- Molecular Weight:
- 138.16
- MOL File:
- 91-16-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/14 11:56:19
| Melting point | 15 °C(lit.) |
|---|---|
| Boiling point | 206-207 °C(lit.) |
| Density | 1.084 g/mL at 25 °C(lit.) |
| vapor pressure | 0.63 hPa (25 °C) |
| FEMA | 3799 | 1,2-DIMETHOXYBENZENE |
| refractive index |
n |
| Flash point | 189 °F |
| storage temp. | Store below +30°C. |
| solubility | 6.69g/l insoluble |
| form | Powder |
| color | White to cream |
| Odor | at 1.00 % in dipropylene glycol. sweet creamy vanilla phenolic musty |
| Odor Type | vanilla |
| Water Solubility | Soluble in alcohol, diethyl ether, acetone, and methanol. Slightly soluble in water. |
| FreezingPoint | 21.0 to 23.0 ℃ |
| Merck | 14,9956 |
| JECFA Number | 1248 |
| BRN | 1364621 |
| Dielectric constant | 4.0899999999999999 |
| InChIKey | ABDKAPXRBAPSQN-UHFFFAOYSA-N |
| LogP | 1.75-2.22 at 25℃ |
| CAS DataBase Reference | 91-16-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1,2-dimethoxy-(91-16-7) |
| EPA Substance Registry System | Veratrole (91-16-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-20/21/22 | |||||||||
| Safety Statements | 36-23-24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | CZ6475000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29093090 | |||||||||
| Toxicity | LD50 in rats, mice (mg/kg): 1360, 2020 orally (Jenner) | |||||||||
| NFPA 704 |
|
1,2-Dimethoxybenzene price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W379905 | 1,2-Dimethoxybenzene ≥99%, FG | 91-16-7 | 1SAMPLE | ₹4990.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W379905 | 1,2-Dimethoxybenzene ≥99%, FG | 91-16-7 | 1KG | ₹7231.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W379905 | 1,2-Dimethoxybenzene ≥99%, FG | 91-16-7 | 5KG | ₹25741.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.08529 | Pyrocatechol dimethyl ether for synthesis | 91-16-7 | 250ML | ₹4090 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2469 | Guaiacol Impurity C Pharmaceutical Secondary Standard; Certified Reference Material | 91-16-7 | 100MG | ₹45529.95 | 2022-06-14 | Buy |
1,2-Dimethoxybenzene Chemical Properties,Uses,Production
Chemical Properties
Colorless crystals or liquid. Soluble in alcohol and ether; slightly soluble in water.
Occurrence
Reported present in asparagus (raw and cooked), bonito (dried), broccoli (cooked), cauliflower (cooked), cognac, endive, grape, Gruyere de Comte cheese, guava, leek (raw and heated), olive, peas, rhubarb, rice bran and vanilla extract.
Uses
1,2-Dimethoxybenzene was used to investigate the electroantennogram response of vine weevil, Otiorhynchus sulcatus to plant volatiles.
Preparation
Prepared by methylation of pyrocatechol.
Definition
ChEBI: A dimethoxybenzene with the methoxy groups at ortho-positions.
General Description
1,2-Dimethoxybenzene reacts with Li{N(SO2CF3)2} to yield molecular crystal [Li{N(SO2CF3)2}{C6H4(OCH3)2}2] having solid-state lithium ion conductivity. It is a potential pollinator attractant of the nocturnal moth Hadena bicruris.
Toxicology
Data from 1,2-dimethoxybenzene and read-across analog 1,4-dimethoxybenzene (CAS # 150-78-7) show that 1,2-dimethoxybenzene is not expected to be genotoxic. Data show that there are no safety concerns for 1,2-dimethoxybenzene for skin sensitization under the current declared levels of use. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to 1,2-dimethoxybenzene is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; 1,2-dimethoxybenzene is not expected to be phototoxic/photoallergenic. For the environmental endpoints, 1,2-dimethoxybenzene is not a PBT as per the IFRA Environmental Standards, and its risk quotients (i.e., PEC/PNEC) for the aquatic environment, based on its current volume of use in Europe and North America, are < 1
Purification Methods
Steam distil veratrole, then fractionally distil it from BaO, CaH2 or Na. Crystallise it from *benzene or low-boiling pet ether at 0o. Fractionally crystallise it from its melt. Store it over anhydrous Na2SO4. [Beilstein 6 IV 5564.]
1,2-Dimethoxybenzene Preparation Products And Raw materials
Raw materials
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