7-KETOCHOLESTEROL

CAS No.: 566-28-9

Chemical Name:: 7-KETOCHOLESTEROL

Synonyms: 7-oxocholesterol;Ketocholesterol;5-cholesten-3B-ol-7-one;5-cholesten-3β-ol-7-one;5-Cholesten-3β-ol-7-one;sc4722;7-KetoC;7-oxo-cholestero;7-KETOCHOLESTEROL;7-Ketocholesterolk

CBNumber:: CB7158120

Molecular Formula:: C27H44O2

Molecular Weight:: 400.65

MOL File:: 566-28-9.mol

MSDS File:: SDS

Modify Date:: 2023/5/18 11:31:16

Request For Quotation

7-KETOCHOLESTEROL Properties

Melting point	158-160°C
Boiling point	463.26°C (rough estimate)
Density	1.0044 (rough estimate)
refractive index	1.4480 (estimate)
storage temp.	room temp
solubility	Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	14.68±0.70(Predicted)
color	Crystals from CHCl3/Et2O

SAFETY

Risk and Safety Statements

WGK Germany	3
RTECS	FZ8708000

7-KETOCHOLESTEROL price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C2394	5-Cholesten-3β-ol-7-one ≥90%	566-28-9	100MG	₹5856.33	2022-06-14	Buy
Sigma-Aldrich(India)	C2394	5-Cholesten-3β-ol-7-one ≥90%	566-28-9	250MG	₹11734.3	2022-06-14	Buy
Sigma-Aldrich(India)	C2394	5-Cholesten-3β-ol-7-one ≥90%	566-28-9	1G	₹25373.8	2022-06-14	Buy

Product number	Packaging	Price	Buy
C2394	100MG	₹5856.33	Buy
C2394	250MG	₹11734.3	Buy
C2394	1G	₹25373.8	Buy

7-KETOCHOLESTEROL Chemical Properties,Uses,Production

Description

7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL. It is produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol by the cytochrome P450 (CYP) isoform CYP7A1. 7-keto Cholesterol inhibits CYP7A1 (IC₅₀ = ~1 μM). It induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state via NLRP3 inflammasome activation in vitro. Intraocular implantation of 7-keto cholesterol coated wafers increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye. Levels of 7-keto cholesterol in lipid deposits are increased in a variety of chronic diseases, including atherosclerosis, Alzheimer''s disease, and age-related macular degeneration.

Chemical Properties

Off-White Solid

Uses

A metabolite of Cholesterol

Definition

ChEBI: A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.

General Description

7-ketocholesterol is a major oxidation product of cholesterol.

Safety Profile

Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes

7-KETOCHOLESTEROL Preparation Products And Raw materials

Raw materials

CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL 7BETA-HYDROXYCHOLESTEROL Cholesterol

Preparation Products

7-KETOCHOLESTEROL Suppliers

Global( 100)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3772	58	Inquiry
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	China	8672	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	China	40067	58	Inquiry
Shanghai Beiwanta Biotechnology Co., Ltd.	021-67187366 19901745723	China	9262	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Chengdu Biopurify Phytochemicals Ltd.	58
Shaanxi Didu New Materials Co. Ltd	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Shanghai Beiwanta Biotechnology Co., Ltd.	58

7-KETOCHOLESTEROL Spectrum

7-KETOCHOLESTEROL(566-28-9)MS 7-KETOCHOLESTEROL(566-28-9)¹HNMR 7-KETOCHOLESTEROL(566-28-9)IR1 7-KETOCHOLESTEROL(566-28-9)IR2

566-28-9(7-KETOCHOLESTEROL)Related Search:

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL 25-HYDROXYCHOLESTEROL 7BETA-HYDROXYCHOLESTEROL Cholesterol 7-KETOCHOLESTEROL ACETATE

22-KETOCHOLESTEROL 22-KETOCHOLESTEROL ACETATE 5-CHOLESTEN-3-BETA-OL-7-ONE BENZOATE 7-oxocholest-5-en-3-beta-yl acetate 25-HYDROXYCHOLESTEROL, 7-KETONE

7-KETO CHOLESTEROL, [1,2-3H] 5-CHOLESTEN-3-BETA, 25-DIOL-7-ONE ACETATE 7-KETOCHOLESTEROL 7-KETOCHOLESTEROL-D7,7-KETOCHOLESTEROL-25,26,26,26,27,27,27-D7 5,25R-SPIROSTEN-3BETA-OL-7-ONE

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7-KETOCHOLESTEROL 5-CHOLESTEN-3BETA-OL-7-ONE 3BETA-HYDROXY-5-CHOLESTEN-7-ONE Cholest-5-en-3beta-ol-7-one 3-hydroxy-5-cholestene-7-one (3-beta)-cholest-5-en-7-on 3-beta-hydroxy-cholest-5-en-7-on 3-HYDROXY-5-CHOLESTENE-7-ONE;7-KETOCHOLESTEROL 3-beta-hydroxycholest-5-en-7-one 7-oxo-cholestero 7-oxocholesterol sc4722 5-cholesten-3B-ol-7-one Cholest-5-en-7-one, 3-hydroxy-, (3.beta.)- 3β-hydroxy-5-cholesten-7-one 5-cholesten-3β-ol-7-one 5A-CHOLESTAN-3B-OL-7-ONE 3-hydroxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,3,4,8,9,11,12,14,15,1 6,17-dodecahydrocyclopenta[a]phenanthren-7-one (3)-3-Hydroxycholest-5-en-7-one 3-Hydroxycholest-5-en-7-one Cholest-5-en-3-ol-7-one 3β-Hydroxy-5-cholesten-7-one, 7-Ketocholesterol 7-KetoC (3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-3-hydroxy-10,13-dimethyl-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one (3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one Cholest-5-en-7-one, 3-hydroxy-, (3b)- 7-Ketocholesterolk 7-Keto Cholesterol (~98%) 7-Ketocholesterol (Solution) Ketocholesterol Cholesterol 7-Keto Cholest-5-en-7-one, 3-hydroxy-, (3β)- Cholesterol Impurity 23 5-Cholesten-3β-ol-7-one HMG-CoA reductase,inhibit,7 Ketocholesterol,Endogenous Metabolite,Inhibitor,coronary artery disease,7-Ketocholesterol,7Ketocholesterol,cholesterol biosynthesis,orphan disease Cholester-3-hydroxy-5-en-7-one 566-28-9 Lipids Cholesterol and Derivatives Sterols BioChemical Biochemicals and Reagents Intermediates & Fine Chemicals Pharmaceuticals Steroids