5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
- CAS No.
- 648450-29-7
- Chemical Name:
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
- Synonyms
- AS605240;AS-605240, >=98%;AS-605240(AS 605240);PI 3-Kinase Inhibitor (AS605240);PI 3-Kγ Inhibitor AS-605240 AS605240;PI 3-Kinase Inhibitor (AS605240) B-0301;AS-605240, 98%, a specific inhibitor of PI3Kγ;PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem;5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione;5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
- CBNumber:
- CB72100624
- Molecular Formula:
- C12H7N3O2S
- Molecular Weight:
- 257.27
- MOL File:
- 648450-29-7.mol
- Modify Date:
- 2023/6/8 9:01:56
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P271-P261-P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934100090 | |||||||||
| NFPA 704 |
|
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A0233 | AS605240 ≥98% (HPLC) | 648450-29-7 | 5MG | ₹14624.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A0233 | AS605240 ≥98% (HPLC) | 648450-29-7 | 25MG | ₹52457.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 528106 | PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem The PI 3-Kγ Inhibitor, also referenced under CAS 648450-29-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily | 648450-29-7 | 5MG | ₹20250 | 2022-06-14 | Buy |
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Chemical Properties,Uses,Production
Uses
AS605240 has been used:
- as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
- as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
- as a class 1A PI3K inhibitor?to treat CD4+?T cells.
Biological Activity
Potent and selective inhibitor of PI 3-kinase γ (PI3K γ ) (IC 50 = 8 nM). Displays 30-fold selectivity over PI3K δ and PI3K β and 7.5-fold selectivity over PI3K α . Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
Biochem/physiol Actions
AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | China | 694 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
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