Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >AS 604850

AS 604850

AS 604850 Structure
CAS No.
648449-76-7
Chemical Name:
AS 604850
Synonyms
CS-538;AS 604850;AS-604850;AS 604850;AS 604850 USP/EP/BP;PI 3-Kγ Inhibitor II;AS604850; AS 604850; AS-604850;PI 3-Kinase Inhibitor (AS604850);PI 3-Kinase Inhibitor (AS604850) B-0302;PI 3-Kγ Inhibitor II AS-604850 AS604850;PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem
CBNumber:
CB5972768
Molecular Formula:
C11H5F2NO4S
Molecular Weight:
285.22
MOL File:
648449-76-7.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:18
Request For Quotation

AS 604850 Properties

Density 1.71
storage temp. 2-8°C
solubility DMSO: >10mg/mL
form solid
pka 7.07±0.20(Predicted)
color off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P280
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37
WGK Germany  3

AS 604850 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A0231 AS 604850 ≥98% (HPLC), solid 648449-76-7 5MG ₹19658.2 2022-06-14 Buy
Sigma-Aldrich(India) A0231 AS 604850 ≥98% (HPLC), solid 648449-76-7 25MG ₹79866.85 2022-06-14 Buy
Sigma-Aldrich(India) 528108 PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem The PI 3-Kγ Inhibitor II, also referenced under CAS 648449-76-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primari 648449-76-7 5MG ₹20250 2022-06-14 Buy
Product number Packaging Price Buy
A0231 5MG ₹19658.2 Buy
A0231 25MG ₹79866.85 Buy
528108 5MG ₹20250 Buy

AS 604850 Chemical Properties,Uses,Production

Description

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of the inositol ring to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kγ is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits. AS-604850 is a selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 μM for the human recombinant γ, δ, β, and α isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 μM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

AS 604850 Preparation Products And Raw materials

Raw materials

Preparation Products

AS 604850 Suppliers

Global( 108)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd +86-86-22-87899925 +86-8618522618860 China 694 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

AS 604850 Spectrum

AS 604850(648449-76-7)1HNMR

648449-76-7(AS 604850)Related Search:

Thianaphthene DIBENZAZEPINE Dibenzothiophene PD 173074 Selumetinib
Nintedanib PHT-427 OSU-03012 (AR-12) AT9283
chevron_left

1of2

chevron_right
AS 604850 PI3Kγ inhibitor, 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione PI 3-Kinase Inhibitor (AS604850) B-0302 (Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione AS-604850;AS 604850 PI 3-Kγ Inhibitor II 5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]thiazolidine-2,4-dione PI 3-Kinase Inhibitor (AS604850) CS-538 AS604850; AS 604850; AS-604850 PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem 2,4-Thiazolidinedione, 5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]- AS 604850 USP/EP/BP PI 3-Kγ Inhibitor II AS-604850 AS604850 5-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione 648449-76-7 C11H5F2NO4S Akt mTOR PI3K Inhibitors