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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Structure
  • ₹14624.58 - ₹52457.95
  • Product name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
  • CAS: 648450-29-7
  • MF: C12H7N3O2S
  • MW: 257.27
  • EINECS:
  • MDL Number:MFCD11100415
  • Synonyms:5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione;AS605240;5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione;PI 3-Kinase Inhibitor (AS605240) B-0301;AS-605240, >=98%;(E)-5-(quinoxalin-6-ylMethylene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-(6-quinoxalinylMethylene)-;AS-605240(AS 605240)
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberA0233
  • Product descriptionAS605240 ≥98% (HPLC)
  • Packaging25MG
  • Price₹52457.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number528106
  • Product descriptionPI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem The PI 3-Kγ Inhibitor, also referenced under CAS 648450-29-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily
  • Packaging5MG
  • Price₹20250
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA0233
  • Product descriptionAS605240 ≥98% (HPLC)
  • Packaging5MG
  • Price₹14624.58
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A0233 AS605240 ≥98% (HPLC) 25MG ₹52457.95 2022-06-14 Buy
Sigma-Aldrich(India) 528106 PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem The PI 3-Kγ Inhibitor, also referenced under CAS 648450-29-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily 5MG ₹20250 2022-06-14 Buy
Sigma-Aldrich(India) A0233 AS605240 ≥98% (HPLC) 5MG ₹14624.58 2022-06-14 Buy

Properties

Density :1.553±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble1mg/mL, clear (warmed)
pka :6.02±0.20(Predicted)
form :powder
color :, faint red to orange to dark brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

PI 3-Kγ Inhibitor is a cell-permeable thiazolidinedione compound that acts as a potent, selective, and ATP-competitive inhibitor of PI 3-kinase γ (PI 3-Kγ) (Ki = 7.8 nM; IC50 = 8 nM, 60 nM, 270 nM, 300 nM for p110-γ, α, β and δ-isoforms, respectively). PI 3-Kγ Inhibitor does not affect the activity of a wide panel of kinases, receptors, enzymes, and ion channels even at concentrations as high as 1 μM. It selectively blocks MCP-1-, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human monocytic cell line THP-1 (IC50 = 181 nM). PI 3-Kγ Inhibitor has also been shown to exhibit efficacy in reducing neutrophil chemotaxis in murine peritonitis and arthritis models.

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