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ChemicalBook > Product Catalog >Organic Chemistry >Amides >Amino compound >5-Dehydro Tolvaptan

5-Dehydro Tolvaptan

5-Dehydro Tolvaptan Structure
CAS No.
137973-76-3
Chemical Name:
5-Dehydro Tolvaptan
Synonyms
Dehydrotolvaptan;5-Dehydro Tolvaptan;Tolvaptan Intermediate;Tolvaptan 5-Oxo Analog;Tolvaptan impurity 5 (DM-21826);7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-ox...;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methy;N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbe;7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
CBNumber:
CB72500620
Molecular Formula:
C26H23ClN2O3
Molecular Weight:
446.93
MOL File:
137973-76-3.mol
MSDS File:
SDS
Modify Date:
2024/3/7 9:17:34
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5-Dehydro Tolvaptan Properties

Melting point >118°C (dec.)
Boiling point 593.2±50.0 °C(Predicted)
Density 1.307
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 12.97±0.70(Predicted)
color White to Off-White
InChIKey VENGMROMZOKURN-UHFFFAOYSA-N
SMILES C(NC1=CC=C(C(N2C3=CC=C(Cl)C=C3C(=O)CCC2)=O)C(C)=C1)(=O)C1=CC=CC=C1C

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H413
Precautionary statements  P501-P273-P270-P264-P301+P312+P330

5-Dehydro Tolvaptan Chemical Properties,Uses,Production

Preparation

To a 3 L reactor was added 1- (4-amino-2-methylbenzoyl) -7-chloro-5-oxo-2,3,4,5-tetrahydro- 1 H- 1 -benzazepine (70. 0 g, 212.90 mmol), dichloromethane (560 ml) and distilled water (140 ml), and the mixture was stirred for 1 hour. Magnesium hydroxide (14.90 g, 14.90 mmol) was added to the reaction mixture at 10 ° C. or lower, and the mixture was stirred for 30 minutes. 2-Methylbenzoyl chloride (30.42 ml) was gradually added to the reaction mixture, stirring for 3 hours. The reaction mixture was filtered to remove magnesium hydroxide, and the pH of the reaction mixture was adjusted to pH 8 to 9 using an aqueous sodium hydroxide solution, and then the organic layer was separated. The obtained organic layer was dried with sodium sulfate (Na 2 SO 4), filtered, and concentrated under reduced pressure to give 5-Dehydro Tolvaptan (yield: 96 percent).

5-Dehydro Tolvaptan Preparation Products And Raw materials

Raw materials

N-(4-bromo-3-methylphenyl)-2-methylbenzamide 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 2-Methyl-4-(2-methylbenzamido)benzoic acid carbon monoxide

Preparation Products

5-Dehydro Tolvaptan Suppliers

Global( 135)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Greenovel life sciences Pvt Ltd Hyderabad, India 138 58 Inquiry
Varanous Labs Pvt Ltd +91-7036248882 +91-7036248882 Hyderabad, India 1541 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Cubane Pharmaceuticals LLP +91-9825323764 +91-9825323764 Gujarat, India 75 58 Inquiry
Apiqule Pharmachem LLP +91-9537957857 +91-9904897541 Gujarat, India 21 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Manus Aktteva +91 (79) 6512-3395 New Delhi, India 581 34 Inquiry
Enki Biopharmaceuticals (Shanghai) Limited +86-0086-2157680326 +8613916707528 China 46 58 Inquiry
Supplier Advantage
Greenovel life sciences Pvt Ltd 58
Varanous Labs Pvt Ltd 58
Ralington Pharma 58
Cubane Pharmaceuticals LLP 58
Apiqule Pharmachem LLP 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Manus Aktteva 34
Enki Biopharmaceuticals (Shanghai) Limited 58

137973-76-3(5-Dehydro Tolvaptan)Related Search:

(R)-(+)-Tolvaptan Ethyl 7-Chloro-5-oxo-1-toxyl-2,3,4,5,-tetrahydro-1H-benzo[b]azepine-4-carboxylate Tolvaptan Impurity 18 Tolvaptan Impurity 13 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester
Tolvaptan Impurity 21 Tolvaptan Impurity 3 (DM-4104) Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17
Tolvaptan impurity 2 Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26
Tolvaptan 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
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N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbe 5-Dehydro Tolvaptan N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-Methylphenyl)-2-MethylbenzaMide Dehydrotolvaptan N-[4-[7-Chloro-2,3,4,5-Tetrahydro-5-oxo-1H-1-Benzazepine-1-yl)carbonyl]-3-MethylPhenyl]-2-MethylBenzamide N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methy Tolvaptan Intermediate Tolvaptan impurity 5 (DM-21826) Tolvaptan 5-Oxo Analog Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl- N-[4-(7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-ox... N-[4-[(7- chloro -2,3,4,5- tetrahydro -5- oxo -1H-1- benzoazepine -1- yl) carbonyl ]-3- methylphenyl ]-2- methylbenzamide * N-[4-[(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide 137973-76-3 Tolvaptan intermediate