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7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

CAS No.: 137982-91-3

Chemical Name:: 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

Synonyms: 1H-benzo[b]azepine;Tovaptan impurity 32;Tovaptan impurity 12;Tolvaptan Impurity 12;Tolvaptan InterMediates;7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1...;7-chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-2H-1-benzazepin-5-one;7-chloro-1-(2-Methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;7-Chloro-5-oxo-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine;7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

CBNumber:: CB32500622

Molecular Formula:: C18H15ClN2O4

Molecular Weight:: 358.78

MOL File:: 137982-91-3.mol

Modify Date:: 2024/8/12 17:17:06

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7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Properties

Melting point	152 - 155°C
Boiling point	573.3±50.0 °C(Predicted)
Density	1.387
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	-2.58±0.20(Predicted)
color	White to Off-White
InChI	InChI=1S/C18H15ClN2O4/c1-11-9-13(21(24)25)5-6-14(11)18(23)20-8-2-3-17(22)15-10-12(19)4-7-16(15)20/h4-7,9-10H,2-3,8H2,1H3
InChIKey	NNCRQBJNAGEBDM-UHFFFAOYSA-N
SMILES	N1(C(=O)C2=CC=C([N+]([O-])=O)C=C2C)C2=CC=C(Cl)C=C2C(=O)CCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Chemical Properties,Uses,Production

Uses

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one is an intermediate in synthesizing Tolvaptan-d7 (T536652), a labelled Tolvaptan (T536650). It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Suppliers

Global( 131)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Mekong pharmaceuticals pvt ltd	+91-4035163894 +91-8008212221	Telangana, India	129	58	Inquiry
Vepan Pharmatech Pvt Ltd	+91-9908788828 +91-9966094448	Telangana, India	391	58	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
Trignokem International	+91 (40) 2717-0709	New Delhi, India	380	50	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Enki Biopharmaceuticals (Shanghai) Limited	+86-0086-2157680326 +8613916707528	China	46	58	Inquiry
HEBEI BRANT PHARMACEUTICAL CO.,LTD	+86-86-31184455288 +8617736059406	China	17	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry

Supplier	Advantage
Ralington Pharma	58
Mekong pharmaceuticals pvt ltd	58
Vepan Pharmatech Pvt Ltd	58
Manus Aktteva	34
Trignokem International	50
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
Enki Biopharmaceuticals (Shanghai) Limited	58
HEBEI BRANT PHARMACEUTICAL CO.,LTD	58
Capot Chemical Co.,Ltd.	60

137982-91-3(7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one)Related Search:

Ethyl 7-Chloro-5-oxo-1-toxyl-2,3,4,5,-tetrahydro-1H-benzo[b]azepine-4-carboxylate Tolvaptan Impurity 18 Tolvaptan Impurity 13 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester Tolvaptan Impurity 21

Tolvaptan Impurity 3 (DM-4104) Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2

Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 Tolvaptan

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 5-Dehydro Tolvaptan 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

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7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Tolvaptan InterMediates 7-chloro-1-(2-Methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 7-Chloro-1,2,3,4-Tetrahydro-1-(2-Methyl-4-Nitrobenzoyl)-5H-1-Benzazepine-5-One 7-chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-2H-1-benzazepin-5-one 7-chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one Tolvaptan Impurity 12 5H-1-Benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)- 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one CAS 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1... 1H-benzo[b]azepine 7- chloro -1,2,3,4- tetrahydro -1-(2- methyl -4- nitrobenzoyl) -5H-1- benzoazepine -5- one * Tovaptan impurity 32 Tovaptan impurity 12 7-chloro-1-(2-methyl-4-(2-methylbenzamido)benzoyl)-2,3-dihydro-1H-benzo[b]azepin-5-yl 2-methylbenzoate 7-Chloro-5-oxo-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine 137982-91-3 Pharmaceutical Intermediates