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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

CAS No.: 160129-45-3

Chemical Name:: 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

Synonyms: 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 29;Tovaptan impurity 24;Tolvaptan Impurity 29;7-chloro-2,3,4,5-tetrahydro-;7-Chlorobenzo[b]azepan-5-one;7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one;7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one;7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone;Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one

CBNumber:: CB7477186

Molecular Formula:: C10H10ClNO

Molecular Weight:: 195.65

MOL File:: 160129-45-3.mol

MSDS File:: SDS

Modify Date:: 2024/7/31 17:39:26

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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Properties

Melting point	103.0 to 107.0 °C
Boiling point	356.5±41.0 °C(Predicted)
Density	1.234±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	2.36±0.20(Predicted)
color	Off-White to Pale Yellow
InChI	InChI=1S/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2
InChIKey	AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES	N1C2=CC=C(Cl)C=C2C(=O)CCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	T
Risk Statements	25
Safety Statements	45
HS Code	2933998090

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	C2896	7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one min. 98.0 %	160129-45-3	1G	₹8200	2022-05-26	Buy
TCI Chemicals (India)	C2896	7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one min. 98.0 %	160129-45-3	5G	₹20800	2022-05-26	Buy

Product number	Packaging	Price	Buy
C2896	1G	₹8200	Buy
C2896	5G	₹20800	Buy

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Synthesis

The synthetic method of 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one comprises the following steps: carrying out an acylation reaction between 4-chloroaniline and succinic anhydride to obtain 4-(4-chloroaniline)-4-oxobutyric acid; carrying out an intramolecular Friedel-Craft reaction on 4-(4-chloroaniline)-4-oxobutyric acid to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one; reacting 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one with ethylene glycol to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal; reducing 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal, and carrying out de-ketalation under an acidic condition to obtain 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one.

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

5-Dehydro Tolvaptan

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Suppliers

Global( 288)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Urantiis Pharmaceuticals Private Limited	+918790703567	AndhraPradesh, India	80	58	Inquiry
Allchem Lifescience Pvt. Ltd	+919867655500	Gujarat, India	971	58	Inquiry
Greenovel life sciences Pvt Ltd		Hyderabad, India	138	58	Inquiry
Malladi Drugs AND Pharmaceuticals Limited	+91-9004653310 +91-9003056437	Tamil Nadu, India	69	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Cubane Pharmaceuticals LLP	+91-9825323764 +91-9825323764	Gujarat, India	75	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry

Supplier	Advantage
Urantiis Pharmaceuticals Private Limited	58
Allchem Lifescience Pvt. Ltd	58
Greenovel life sciences Pvt Ltd	58
Malladi Drugs AND Pharmaceuticals Limited	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
Ralington Pharma	58
Cubane Pharmaceuticals LLP	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Spectrum

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one(160129-45-3)¹HNMR

160129-45-3(7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one)Related Search:

2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2

Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 6-CHLORO-1H-BENZIMIDAZOLE

6-Chloro-2-benzoxazolethiol 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one

2,3,4,5-Tetrahydro-1H-benzo[b]azepine 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 7-CHLORO-9-METHOXY-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

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7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one 5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro- 7-Chlorobenzo[b]azepan-5-one 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one Tolvaptan Impurity 29 7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE 7-chloro-2,3,4,5-tetrahydro- 7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one > 7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine Tovaptan impurity 29 Tovaptan impurity 24 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one 160129-45-3 Building Blocks/Intermediates Tolvaptan intermediate