ChemicalBook > Product Catalog >Organic Chemistry >Nitrogen Compounds >1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

CAS No.: 137977-97-0

Chemical Name:: 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

Synonyms: 1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 39;Tolvaptan Impurity 10;Histaprodifen Impurity 1;Tolvaptan Intermediate 3;1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1...;1-(4-amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-2H-1-benzazepin-5-one;1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one;1-(4-aMino-2-Methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;7-Chloro-5-oxo-1-(2-methyl-4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine

CBNumber:: CB02500621

Molecular Formula:: C18H17ClN2O2

Molecular Weight:: 328.79

MOL File:: 137977-97-0.mol

Modify Date:: 2024/1/2 18:26:26

Request For Quotation

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Properties

Melting point	186-189°C
Boiling point	565.4±50.0 °C(Predicted)
Density	1.320
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly)
pka	2.28±0.10(Predicted)
form	Solid
color	Off-White to Pale Yellow
InChI	InChI=1S/C18H17ClN2O2/c1-11-9-13(20)5-6-14(11)18(23)21-8-2-3-17(22)15-10-12(19)4-7-16(15)21/h4-7,9-10H,2-3,8,20H2,1H3
InChIKey	FLJCJPKXJWRZJB-UHFFFAOYSA-N
SMILES	N1(C(=O)C2=CC=C(N)C=C2C)C2=CC=C(Cl)C=C2C(=O)CCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H312-H332
Precautionary statements	P280

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Chemical Properties,Uses,Production

Uses

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V 2 receptor antagonist.

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Suppliers

Global( 139)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Greenovel life sciences Pvt Ltd		Hyderabad, India	138	58	Inquiry
Malladi Drugs AND Pharmaceuticals Limited	+91-9004653310 +91-9003056437	Tamil Nadu, India	69	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Apiqule Pharmachem LLP	+91-9537957857 +91-9904897541	Gujarat, India	21	58	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Enki Biopharmaceuticals (Shanghai) Limited	+86-0086-2157680326 +8613916707528	China	46	58	Inquiry
Changzhou Rokechem Technology Co., Ltd.	18758118018	China	255	58	Inquiry

Supplier	Advantage
Greenovel life sciences Pvt Ltd	58
Malladi Drugs AND Pharmaceuticals Limited	58
Ralington Pharma	58
Apiqule Pharmachem LLP	58
Manus Aktteva	34
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
Enki Biopharmaceuticals (Shanghai) Limited	58
Changzhou Rokechem Technology Co., Ltd.	58

137977-97-0(1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one)Related Search:

Tolvaptan Impurity 11 Tolvaptan Impurity 26 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

Tolvaptan Impurity 3 (DM-4104) Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one 2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 4 (DM-4105)

Ethyl 7-Chloro-5-oxo-1-toxyl-2,3,4,5,-tetrahydro-1H-benzo[b]azepine-4-carboxylate 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester Tolvaptan Impurity 21 Tolvaptan Impurity 18 Tolvaptan Impurity 13

Tolvaptan Impurity 17 Tolvaptan impurity 2 Tolvaptan Impurity 20

chevron_left

1of4

chevron_right

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 5H-1-Benzazepin-5-one, 1-(4-aMino-2-Methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro- 1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one 1-(4-aMino-2-Methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 1-(4-Amino-2-Methylbenzoyl)-7-Chloro-1,2,3,4-Tetrahydro-5H-1-benzazepine-5-One 1-(4-amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-2H-1-benzazepin-5-one Tolvaptan Intermediate 3 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1... 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one Tolvaptan Impurity 10 1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 1-(4- amino -2- methylbenzoyl) -7- chloro -1,2,3,4- tetrahydro -5H-1- benzoazepine -5- one * Tovaptan impurity 39 7-Chloro-5-oxo-1-(2-methyl-4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine Histaprodifen Impurity 1 137977-97-0 Pharmaceutical Intermediates 137977-97-0