Hydromorphone hydrochloride
- CAS No.
- 71-68-1
- Chemical Name:
- Hydromorphone hydrochloride
- Synonyms
- HYDROMORPHONE HCL;dilaudidhydrochloride;Hydromorphine hydrochloride;HYDROMORPHONE HYDROCHLORIDE;XHILEZUETWRSHC-NRGUFEMZSA-N;HYDROMORPHONEHYDROCHLORIDE,USP;dihydromorphinonehydrochloride;Hydromorphone hydrochloride salt;Morphinone, dihydro-, hydrochloride;hydromorphone hydrochloride solution
- CBNumber:
- CB7250921
- Molecular Formula:
- C17H20ClNO3
- Molecular Weight:
- 321.8
- MOL File:
- 71-68-1.mol
- Modify Date:
- 2023/6/8 9:02:58
| Melting point | >280°C (dec.) |
|---|---|
| alpha | D25 -133° |
| Density | 1.1451 (rough estimate) |
| refractive index | 1.6470 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: >10 mg/mL |
| form | A crystalline solid |
| EPA Substance Registry System | Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride (1:1), (5.alpha.) (71-68-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H336 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 16-36/37-45 | |||||||||
| RIDADR | UN 1230 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QD2625000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2939110000 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 61-96 i.v. (Buchwald, Eadie) | |||||||||
| NFPA 704 |
|
Hydromorphone hydrochloride Chemical Properties,Uses,Production
Description
Hydromorphone hydrochloride is a pure opioid agonist with the principal therapeutic activity of analgesia. It has an analgesic potency approximately two to eight times greater than that of morphine and has a rapid onset of action. A significant feature of the analgesia is that it can occur without loss of consciousness.
Chemical Properties
White Solid
Uses
Analgesic (narcotic). Preparation by electrolytic reduction of Morphine. Controlled substance (opiate).
Clinical Use
Hydromorphone is a potent μ agonist (eight times greater than morphine) that is used to treat severe pain. It is available in intramuscular, intravenous, subcutaneous, oral, and rectal dosage forms. Like all strong μ agonists, hydromorphone is addicting and is a Schedule II drug. Hydromorphone has an oral:parenteral potency ratio of 5:1. The plasma half-lives after parenteral and oral dosage are 2.5 and 4 hours, respectively.
Safety Profile
Poison by subcutaneous and intravenous routes. Experimental teratogenic effects. A powerful analgesic. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also MORPHINE.
Hydromorphone hydrochloride Preparation Products And Raw materials
Hydromorphone hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alfa Chemistry | +1-5166625404 | United States | 21317 | 58 | Inquiry |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | China | 3545 | 58 | Inquiry |
| Hebei Best Biological Technology Co., Ltd | China | 284 | 58 | Inquiry | |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | China | 3582 | 58 | Inquiry |
| SPECGX LLC | +353 1 6960000 | United States | 29 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd | 18162595016 | China | 9887 | 58 | Inquiry |
| Yichang people Fook Pharmaceutical Co., Ltd. | 0717-6345091,0717-6345030 | China | 6 | 60 | Inquiry |