Vilazodone Hydrochloride
- CAS No.
- 163521-08-2
- Chemical Name:
- Vilazodone Hydrochloride
- Synonyms
- CS-796;EMD 68843;SB 659746A;Vilazodone HCl, >=98%;4-Methylenedioxyphenol;Vilazodone hydrochloride;Vilazodone HCl (EMD 68843;Vilazodone hydrochloride API;Vera trazodone hydrochloride;Vilazodone hydrochloride salt
- CBNumber:
- CB72521214
- Molecular Formula:
- C26H28ClN5O2
- Molecular Weight:
- 477.98582
- MOL File:
- 163521-08-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361d | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Vilazodone Hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1098 | Vilazodone hydrochloride ≥98% (HPLC) | 163521-08-2 | 10MG | ₹6841.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V-023 | Vilazodone hydrochloride solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 163521-08-2 | 1ML | ₹16837.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1098 | Vilazodone hydrochloride ≥98% (HPLC) | 163521-08-2 | 50MG | ₹27668.7 | 2022-06-14 | Buy |
| TCI Chemicals (India) | V0149 | Vilazodone Hydrochloride | 163521-08-2 | 50MG | ₹8600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | V0149 | Vilazodone Hydrochloride | 163521-08-2 | 200MG | ₹14800 | 2022-05-26 | Buy |
Vilazodone Hydrochloride Chemical Properties,Uses,Production
Description
Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50s = 0.2 and 0.5 nM, respectively). It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.
Uses
Vilazodone Hydrochloride, is the salt form of Vilazodone (V265000), which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Antidepressant.
Definition
ChEBI: A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder.
Clinical Use
Althoughseveral synthetic approaches have beenreported,a process-scale synthesis of vilazodone consists of the union of an indole-containing butyl tosylate 284 with a benzofuranyl piperazine whose synthesis is described in the scheme below. Piperazine 280 arises from a Buchwald coupling of commercially available benzofuranyl bromide 279 with piperazine through the use of a unique catalyst system employing the DavePhos ligand. This single coupling step, which has been executed on multigram scale in 70% yield,210 circumvented the need for any protecting group chemistry for either the primary amide within 279 or the piperazine amine functionality. For the preparation of the key indole subunit, Friedel-Crafts acylation of commercially available 5-cyanoindole (281) proceeded in good yield at the 3-position of the indole with 4-chlorobutanoyl chloride in 82% yield. Treatment of the resulting chloroketone with sodium borohydride in refluxing isopropanol converted 282 to the corresponding terminal alcohol 283. Tosylation of this alcohol was followed by displacement with piperazine 280 to give vilazodone hydrochloride (XXV) after acidification.
Vilazodone Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Nosch Labs Pvt Ltd | +91-4048557474 +91-9948222287 | Hyderabad, India | 58 | 58 | Inquiry |
| Zydus Lifesciences Ltd. | +91-0265-2315243 +91-6358895661 | Gujarat, India | 89 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Maps Laboratories Pvt Ltd | +91-9925030826 +91-9925013085 | Gujarat, India | 28 | 58 | Inquiry |
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| GLENMARK LIFE SCIENCES LTD | +91 22 4018 9999 | New Delhi, India | 103 | 58 | Inquiry |
| DR REDDYS LABORATORIES LTD | +91-40-49002900 | New Delhi, India | 201 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Dr. Reddy's Laboratories Ltd | 58 |
| Lupin Ltd | 58 |
| Alembic Pharmaceuticals Limited | 58 |
| Nosch Labs Pvt Ltd | 58 |
| Zydus Lifesciences Ltd. | 58 |
| Ralington Pharma | 58 |
| Maps Laboratories Pvt Ltd | 58 |
| Mylan Laboratories Ltd | 58 |
| GLENMARK LIFE SCIENCES LTD | 58 |
| DR REDDYS LABORATORIES LTD | 58 |