Blonanserin
- CAS No.
- 132810-10-7
- Chemical Name:
- Blonanserin
- Synonyms
- Lonasen;CS-625;AD 5423;Bunanserin;Blonanserin;Blonansarin –;Blonanserin IH;Blonanserin >Blonanserin CRS;Blonanserin Crude
- CBNumber:
- CB91011174
- Molecular Formula:
- C23H30FN3
- Molecular Weight:
- 367.5
- MOL File:
- 132810-10-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:17
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H413 | |||||||||
| Precautionary statements | P273-P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | GY0175140 | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | mouse,LD,oral,> 500mg/kg (500mg/kg),United States Patent Document. Vol. #5021421, | |||||||||
| NFPA 704 |
|
Blonanserin price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B7188 | Blonanserin ≥98% (HPLC) | 132810-10-7 | 5MG | ₹8746.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B7188 | Blonanserin ≥98% (HPLC) | 132810-10-7 | 25MG | ₹33460.08 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B4565 | Blonanserin | 132810-10-7 | 25MG | ₹7800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B4565 | Blonanserin | 132810-10-7 | 100MG | ₹9800 | 2022-05-26 | Buy |
Blonanserin Chemical Properties,Uses,Production
Description
Blonanserin, a dual antagonist of dopamine D2 and serotonin 5-HT2 receptors, was launched past year in Japan for the oral treatment of psychosis and schizophrenia. It is the latest entry in the class of atypical antipsychotic agents to reach the market. Blonanserin exhibits high affinity for D2 and 5-HT2 receptors (IC50 23.6 and 9.85 nM, respectively). Its affinity for D2 receptors is very close to that of haloperidol and risperidone, whereas the affinity for 5-HT2 receptors is about 7 times higher than that of haloperidol and 10 times lower than that of risperidone.Blonanserin is chemically derived in three steps starting with a polyphosphoric acid mediated condensation reaction of cyclooctanone with 4-fluorobenzoylacetonitrile. The resultant 4-fluorophenylcycloocta[b]pyridin-2-one intermediate is converted to the corresponding 2-chloro derivative by treatment with phosphoryl chloride and subsequently condensed with 1-ethylpiperazine to afford blonanserin.
Chemical Properties
Pale Yellow Solid
Uses
Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 (Ki, 14.8 nM) and serotonin 5-HT2(Ki, 3.98 nM) receptors antagonist properties.
Blonanserin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Chynops Pharma | +919998000404 | Gujarat, India | 39 | 58 | Inquiry |
| Smilax Laboratories Limited | +91-8919514965 +91-8008333438 | Telangana, India | 28 | 58 | Inquiry |
| Amuna Pharmaceuticals LLP | +91-7940397667 +91-8700823105 | Gujarat, India | 14 | 58 | Inquiry |
| Acute Research | +91-9825068697 +91-9825068697 | Gujarat, India | 43 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Globela Industry Pvt Ltd | +91-2616158000 +91-9998199919 | Gujarat, India | 98 | 58 | Inquiry |
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| Lakshmi Farmachem | +91-9948795885 +91-9550886476 | Telangana, India | 407 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SNECOFRi Pvt Ltd | 58 |
| Chynops Pharma | 58 |
| Smilax Laboratories Limited | 58 |
| Amuna Pharmaceuticals LLP | 58 |
| Acute Research | 58 |
| Ralington Pharma | 58 |
| Globela Industry Pvt Ltd | 58 |
| Mylan Laboratories Ltd | 58 |
| Lakshmi Farmachem | 58 |
| CLEARSYNTH LABS LTD. | 58 |
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