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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >HSP e.g. HSP90 inhibitors >CH5138303

CH5138303

CH5138303 Structure
CAS No.
959763-06-5
Chemical Name:
CH5138303
Synonyms
CH5138303;CH5138303cas;CH5138303_Hsp90;CH5138303 USP/EP/BP;4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide;4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide;4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid;Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-;4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide
CBNumber:
CB72706190
Molecular Formula:
C19H18ClN5O2S
Molecular Weight:
415.9
MOL File:
959763-06-5.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:16
Request For Quotation

CH5138303 Properties

Boiling point 813.1±75.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
storage temp. Desiccate at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
form solid
pka 16.39±0.40(Predicted)
color White to off-white

CH5138303 Chemical Properties,Uses,Production

Description

CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (Kd = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) and displays high oral bioavailability in mice.

CH5138303 Preparation Products And Raw materials

Raw materials

Preparation Products

CH5138303 Suppliers

Global( 49)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 23499 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
ApexBio Technology + 1-832-696-8203 United States 6254 58 Inquiry
Shanghai Weiwei Biological Technology Co., Ltd. 021-55669583 18616258598 CHINA 4398 58 Inquiry
Boao Pike 010-57798038 15652371397 CHINA 6629 58 Inquiry
Supplier Advantage
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
ApexBio Technology 58
Shanghai Weiwei Biological Technology Co., Ltd. 58
Boao Pike 58

959763-06-5(CH5138303)Related Search:

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17-AAG
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CH5138303 Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]- CH5138303_Hsp90 4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide 4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide CH5138303 USP/EP/BP CH5138303cas 959763-06-5 Inhibitors