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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

CAS No.: 1240948-72-4

Chemical Name:: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

Synonyms: Vonoprazan-3;Vonoprazan-024;TAK438 Impurity 32;Vonolazan impurity 3;Vonoprazan Impurity Ⅶ;Vonoprazan Impurity 33;TAK438 Intermediate 3;Vonoprazan Fumarate impurity G;Voronozan initiator 1 impurity I;2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

CBNumber:: CB72722688

Molecular Formula:: C11H6ClFN2

Molecular Weight:: 220.63

MOL File:: 1240948-72-4.mol

MSDS File:: SDS

Modify Date:: 2022/8/26 12:23:07

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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Properties

Boiling point	403.0±45.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	12.88±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Chemical Properties,Uses,Production

Description

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is an important pharmaceutical intermediate. It can be used in the preparation of vorexanol fumarate and vonoprazan, and can also be used as a chemical raw material for the synthesis of other organic compounds.

Uses

2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity 33) is an impurity of Vonoprazan, a potassium-competitive acid blocker (P-CAB) that suppresses gastric acid secretion.

Synthesis

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is synthesised using 2-[2-(2-fluorophenyl)-2-oxoethyl]malononitrile as raw material by chemical reaction. The specific synthesis steps are as follows:
2 g of the intermediate III-1 was dissolved in 40 ml of a solution of hydrochloric acid in ethyl acetate, and the mixture was stirred at room temperature overnight. After the reaction is completed, the solvent is distilled off under reduced pressure to give the compound of 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile, 2.1 g of a white solid with a yield of 96%.

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Suppliers

Global( 124)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
VGS SYNTHESIS PRIVATE LIMITED	+91-9866975588 +91-9866975588	Hyderabad, India	1818	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	18642	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	CHINA	1320	58	Inquiry
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	China	9505	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	China	7121	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23555	58	Inquiry
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	China	9316	58	Inquiry

Supplier	Advantage
VGS SYNTHESIS PRIVATE LIMITED	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Shanghai Yingrui Biopharma Co.,Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hubei Ipure Biology Co., Ltd	58
Shanghai UCHEM Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Baoji Guokang Bio-Technology Co., Ltd.	58

1240948-72-4(2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile)Related Search:

Vonoprazan Fumarate impurity (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol 4-Pyridinesulphonic acid 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-

PYRIDINE-4-SULFONYL CHLORIDE PYRIDINE-2-SULFONIC ACID 3-N,N-dimethylsulfamoylpyridine 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile

1-(5-(2-fluorophenyl)-1-(pyridin-2-ylsulfonyl)-1H-pyrrol-3-yl)-N- methylmethanamine fumarate 5-chloropyridine-3-sulfonyl chloride 1-methylpyridin-1-ium-4-sulfonate 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)- (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide

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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-Pyrrole-3-carbonitrile,2-chloro-5-(2-fluorophenyl)- Vonoprazan Fumarate impurity G Vonoprazan Impurity 33 Vonoprazan Impurity Ⅶ Vonoprazan-024 TAK438 Impurity 32 Vonoprazan impurity 28/2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Vonoprazan impurity SM2-A: 2-chloro-5- (2-fluorophenyl) -1H-pyrrole-3-carbonitrile Vonoprazan-3 Voronozan initiator 1 impurity I 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity） TAK438 Intermediate 3 Vonolazan impurity 3 1240948-72-4 1240948-72-4