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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Isoquinoline compounds >5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Structure
CAS No.
1289646-93-0
Chemical Name:
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
Synonyms
5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride;6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride;Lifitegrast Impurity 5;lifitegrast-impurity IV-3;Lifitegrast Intermediate 2;6-ISOQUINOLINECARBOXYLIC ACID,5,7-DICHLORO-1,2,3,4-TETRAHYDR...;5,7-Dichloro-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid hydrochloride (1:1);6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1;6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)
CBNumber:
CB73137955
Molecular Formula:
C10H10Cl3NO2
Molecular Weight:
282.55
MOL File:
1289646-93-0.mol
Modify Date:
2023/7/12 10:41:40
Request For Quotation

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Properties

InChI InChI=1S/C10H9Cl2NO2.ClH/c11-7-3-5-4-13-2-1-6(5)9(12)8(7)10(14)15;/h3,13H,1-2,4H2,(H,14,15);1H
InChIKey CGXSFPJGZFRGNL-UHFFFAOYSA-N
SMILES ClC1C(=C(Cl)C=C2CNCCC=12)C(=O)O.Cl

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Chemical Properties,Uses,Production

General Description

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride, also known as Lifitegrast Impurity 5, is an impurity of Lifitegrast. Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process.

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Preparation Products And Raw materials

Raw materials

5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Preparation Products

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Suppliers

Global( 97)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
SRIKAR Labs +91-9490599901 +91-9177846399 Telangana, India 60 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
PharmOrgSyn Laboratories Co., Ltd. +86-021-38228826 +86-13916602830 China 140 58 Inquiry
Guangzhou Tosun Pharmaceutical Limited +8618922120635 China 1000 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Hubei Ipure Biology Co., Ltd +8613367258412 China 10326 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
Supplier Advantage
VGS SYNTHESIS PRIVATE LIMITED 58
SRIKAR Labs 58
SynZeal Research Pvt Ltd 58
PharmOrgSyn Laboratories Co., Ltd. 58
Guangzhou Tosun Pharmaceutical Limited 58
Capot Chemical Co.,Ltd. 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
Hubei Ipure Biology Co., Ltd 58
ANHUI WITOP BIOTECH CO., LTD 58

1289646-93-0(5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride)Related Search:

Lifitegrast Impurity 6 Lifitegrast Impurity 3 Lifitegrast Impurity 9 HCl Lifitegrast Impurity 8 2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-[[[(1S)-1-[[3-(methylsulfonyl)phenyl]methyl]-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl]-, 1,1-dimethylethyl ester
lifitegrast benzyl (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate (R)-Benzyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride Ethyl benzofuran-6-carboxylate L-Phenylalanine, N-[(5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl)carbonyl]-3-(methylsulfonyl)-, phenylmethyl ester, hydrochloride (1:1)
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
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6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) 6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1 Lifitegrast Intermediate 2 Lifitegrast Impurity 5 5,7-Dichloro-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid hydrochloride (1:1) lifitegrast-impurity IV-3 6-ISOQUINOLINECARBOXYLIC ACID,5,7-DICHLORO-1,2,3,4-TETRAHYDR... 6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride 1289646-93-0