TETRAMETHYLSUCCINONITRILE
- CAS No.
- 3333-52-6
- Chemical Name:
- TETRAMETHYLSUCCINONITRILE
- Synonyms
- Tmsn;Tetramethylbutanedinitrile;2,2,3,3-Tetramethylsuccinonitrile;cp75475;Tetramethylsuccinotrile;Tetramethylsukcinonitril;tetramethyl-succinonitril;TETRAMETHYLSUCCINONITRILE;tetramethyl-butanedinitril;Tetramethylsuccinodinitril
- CBNumber:
- CB7417335
- Molecular Formula:
- C8H12N2
- Molecular Weight:
- 136.19
- MOL File:
- 3333-52-6.mol
- Modify Date:
- 2023/6/8 17:06:38
| Melting point | 168°C |
|---|---|
| Boiling point | 240.49°C (rough estimate) |
| Density | 1.0700 |
| refractive index | 1.4436 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| Water Solubility | Insoluble in water |
| solubility | Chloroform (Soluble), DMSO (Slightly) |
| form | solid |
| color | White to Almost white |
| EPA Substance Registry System | Tetramethylsuccinonitrile (3333-52-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H311+H331-H371-H373 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25-36/37/38-48/20/21 | |||||||||
| Safety Statements | 26-36/37/39-45-36/37 | |||||||||
| RIDADR | 3439 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 3 mg/m3 (0.5 ppm) [skin] | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | WN4025000 | |||||||||
| HS Code | 2926.90.5050 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| IDLA | 5 ppm | |||||||||
| NFPA 704 |
|
TETRAMETHYLSUCCINONITRILE price More Price(2)
TETRAMETHYLSUCCINONITRILE Chemical Properties,Uses,Production
Chemical Properties
Colorless, solid; odorless. Insoluble in water.
Uses
2,2,3,3-Tetramethylsuccinonitrile is used in preparation of 4,5-Dihydro-1,2,3-triazole derivatives as Farnesyltransferase inhibitors.
General Description
White crystals.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Nitriles, such as TETRAMETHYLSUCCINONITRILE, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. TETRAMETHYLSUCCINONITRILE can react violently with (LiAlH4 + H2O).
Hazard
Toxic by inhalation and skin contact. Headache, nausea, and central nervous system convulsions.
Fire Hazard
Flash point data are not available for TETRAMETHYLSUCCINONITRILE, but TETRAMETHYLSUCCINONITRILE is probably combustible.
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. A human skin irritant and allergen. In the preparation of sponge rubber, an azo compound is used that decomposes to form tetramethylsuccinonitrile or TMSN. Rats exposed to a concentration of 90 ppm exhbit their first convulsion after 1.5-2 hours or less. Rats exposed to concentration of 5.5 pprn exhbited their first convulsions in 27-31 hours and were dead in 31-46 hours. Absorbed by skin. The fatal dose in humans is thought to be about 25 mg/kg of body weight. TSN is slowly detoxified by the body. This nitrile is different from other nitriles in that duosulfate is a poor antidote for intoxication. When heated to decomposition it emits toxic fumes of CNand NOx. See also NITRILES and CYANIDE.
TETRAMETHYLSUCCINONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Alfa Chemistry | United States | 2344 | 58 | Inquiry | |
| Aston Chemical | 13000000000 | United States | 1634 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | China | 35451 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Henan Tianfu Chemical Co.,Ltd. | 55 |
| Career Henan Chemica Co | 58 |
| Alfa Chemistry | 58 |
| Aston Chemical | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 58 |
| LEAP CHEM CO., LTD. | 58 |
| PT CHEM GROUP LIMITED | 58 |
| GIHI CHEMICALS CO.,LIMITED | 58 |
| Aladdin Scientific | 58 |
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