Toltrazuril
- CAS No.
- 69004-03-1
- Chemical Name:
- Toltrazuril
- Synonyms
- MARIGOLD OLEORESIN;Toltrazuri;BAYCOX;Toltrazuil;Baycox, 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylthio)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione;trazuriL;bay-i9142;Bayvi 9142;TOLRAZURIL;Tltrazuril
- CBNumber:
- CB7705830
- Molecular Formula:
- C18H14F3N3O4S
- Molecular Weight:
- 425.38
- MOL File:
- 69004-03-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/5 11:27:04
| Melting point | 194-196°C |
|---|---|
| Density | 1.54±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Toltrazuril is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of toltrazuril in ethanol is approximately 1 mg/ml and approximately 25 mg/ml in DMSO and DMF. |
| pka | 6.47±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26) |
| InChIKey | OCINXEZVIIVXFU-UHFFFAOYSA-N |
| SMILES | N1(C)C(=O)NC(=O)N(C2=CC=C(OC3=CC=C(SC(F)(F)F)C=C3)C(C)=C2)C1=O |
| CAS DataBase Reference | 69004-03-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H410 | |||||||||
| Precautionary statements | P273-P391-P501 | |||||||||
| Hazard Codes | N,Xi | |||||||||
| Risk Statements | 50/53-36/37/38 | |||||||||
| Safety Statements | 60-61-37/39-26 | |||||||||
| RIDADR | UN 3077 | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 29336990 | |||||||||
| NFPA 704 |
|
Toltrazuril Chemical Properties,Uses,Production
Description
Toltrazuril (Baycox®,Procox®) is a triazinon drug thathas broad-spectrum anticoccidial and antiprotozoalactivity. It is not commercially available in the UnitedStates, but it is available in other countries. It is activeagainst both asexual and sexual stages of coccidia byinhibiting nuclear division of schizonts and microga-monts and the wall-forming bodies of macrogamonts. Itmay also be useful in the treatment of neonatal porcinecoccidiosis, EPM, and canine hepatozoonosis.
Toltrazuril and its major metabolite ponazuril (toltrazuril sulfone, Marquis) are triazine-based antiprotozoal drugs that have specific activity against apicomplexan coccidial infections. Toltrazuril is not available within the United States.
Uses
Labelled analog of a triazinetrione anticoccidial. Coccidiostat. Toltrazuril is found to be highly effective against coccidia and is used in controlling coccidiosis. It is acting against all intracellular development stages of coccidia of the merogony (asexual multiplication) and gamogony (sexual phase). All stages are destroyed, thus the mode of action is coccidiocidal.
benefits
Toltrazuril is highly effective and has demonstrated the following benefits:-prevents and reduces the severity of lesions;-stops oocyst shedding;-improves growth rate;-improves feed conversion.
Physiological effects
Toltrazuril is suitable for both therapy and metaphylaxis, by damaging the intracellular developmental stages of Coccidia. Findings from studies suggest it interferes with the division of the nucleus and the activity of mitochondria, which is responsible for respiratory metabolism in the parasite.
Environmental Fate
The metabolite of toltrazuril, toltrazuril sulfone (ponazuril) is a persistent (half-life >1 year) and mobile compound and has adverse effects on both the growth and emergence of plants. Given the persistent properties of ponazuril repeated spreading of manure from treated animals may lead to an accumulation in the soil and consequently a risk to plants. The accumulation of ponazuril in soil together with its mobility also leads to a risk of leaching to groundwater.
Toltrazuril Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| NGL Fine Chem limited | +91-8866366396 +91-8866366396 | Mumbai, India | 26 | 58 | Inquiry |
| Manasvi Life Sciences | +91-9391326151 +91-9490072008 | Hyderabad, India | 39 | 58 | Inquiry |
| Alivira Animal Health Ltd | +91-8976959415 +91-9920774050 | Maharashtra, India | 35 | 58 | Inquiry |
| Heer Pharma Pvt Ltd | +91-9820051881 +91-9820051881 | Maharashtra, India | 102 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Hebei ZB Gamay Biological Technology Co.,Ltd | +8617330018573 | China | 222 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | China | 844 | 58 | Inquiry |
Related articles
- Synthesis and Application of Toltrazuril
- Toltrazuril is an antiprotozoal drug that acts against coccidia parasites.
- Aug 29，2022
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