Tween 80
- CAS No.
- 9005-65-6
- Chemical Name:
- Tween 80
- Synonyms
- POLYSORBATE 80;POLYSORBATE;Tween;SORBITAN MONOOLEATE;Ps80;tuwen;polysorbate80,u.s.p.;POLYSORBATE 81;POLYSORBATUM 80;glycosperseo-20
- CBNumber:
- CB7741359
- Molecular Formula:
- C24H44O6
- Molecular Weight:
- 428.600006103516
- MOL File:
- Mol file
- MSDS File:
- SDS
- Modify Date:
- 2025/3/27 6:45:46
| Melting point | -25 °C |
|---|---|
| Boiling point | >100°C |
| Density | 1.08 g/mL at 20 °C |
| vapor pressure | <1 mm Hg ( 20 °C) |
| FEMA | 2917 | POLYSORBATE 80 |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | -20°C |
| solubility | DMSO (Soluble), Methanol (Slightly) |
| form | viscous liquid |
| Specific Gravity | 1.080 (25/4℃) |
| color | Amber |
| PH | 5-7 (50g/l, H2O, 20℃) |
| PH Range | 6 |
| Odor | mild alcoholic |
| Odor Type | alcoholic |
| biological source | synthetic |
| Water Solubility | 5-10 g/100 mL at 23 ºC |
| Merck | 14,7582 |
| Hydrophilic-Lipophilic Balance (HLB) | 10 |
| LogP | 4.392 (est) |
| EPA Substance Registry System | Polysorbate 80 (9005-65-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 22-36/37/38-37/38-41 | |||||||||
| Safety Statements | 24/25-36/37/39-36-26 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | WG2934000 | |||||||||
| F | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 34021300 | |||||||||
| Hazardous Substances Data | 9005-65-6(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in mice, rats (ml/kg): 7.5, 6.3 i.p. (Varma) | |||||||||
| NFPA 704 |
|
Tween 80 price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W291706 | Polysorbate 80 FG | 9005-65-6 | 1SAMPLE-K | ₹5272.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W291706 | Polysorbate 80 FG | 9005-65-6 | 1KG | ₹7026.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W291706 | Polysorbate 80 FG | 9005-65-6 | 10KG | ₹25940.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W291706 | Polysorbate 80 FG | 9005-65-6 | 25KG | ₹46620 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | STS0204 | ECO TWEEN® 80 viscous liquid | 9005-65-6 | 500ML | ₹8080.8 | 2022-06-14 | Buy |
Tween 80 Chemical Properties,Uses,Production
Characteristics
Tween 80, commercially known as Polysorbate-80, is a viscous, water-soluble Yellow to amber liquid derived from polyethoxylated sorbitan and oleic acid. Tween 80 is structurally similar to the (polyethylene) glycols and used both in injections (0.8-8.0%) and in oral suspension (0.375% w/v). A number of anticancer drugs can be formulated by Tween 80. Typical examples include etoposide and minor groove-binding cyclopropylpyrroloindole analogues like carzelesin.
Chemical Properties
Tween 80 has a faint, characteristic odor and a warm, somewhat bitter taste. It is a mixture of oleate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides.
Uses
Tween 80 is the trade name of a detergent that can be useful in identifying mycobacteria that possess a lipase that splits the compound into oleic acid and polyoxyethylated sorbitol.
Tween 80 is used as an additive for cell culture media. It has numerous effects, e.g. increasing the transformation frequency of Brevibacterium lactofermentum or enhancing the secretion of acid and alkaline phosphatase by Neurospora crassa.
Uses
Tween 80 is a general purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products and cosmetic formulations (o/w emulsifier, viscosity modifier).
Uses
Tween 80 is used as an antistat for PVC and as an antifog for PP, PE, PVC, PS.
Uses
Tween 80 is used as an emulsifier (ice cream, whipped topping) and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations.
Definition
ChEBI: A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.
General Description
Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste.
Polysorbate 80 (Tween 80) is a synthetic surfactant composed of fatty acid esters of polyoxyethylene sorbitan. Polysorbate 80 is usually available as a chemically diverse mixture of different fatty acid esters, with the oleic acid comprising?>?58% of the mix. However, the main component of polysorbate 80 is polyoxyethylene-20-sorbitan monooleate, which is structurally similar to polyethylene glycols. Polysorbate 80 has a molecular weight of 1309.7 Da and a 1.064 g/ml density[1].
Air & Water Reactions
Water soluble.
Reactivity Profile
Tween 80 is incompatible with strong alkalis and oxidizers.
Fire Hazard
Tween 80 is probably combustible.
Biochem/physiol Actions
Tween 80 is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.
Pharmacokinetics
Polysorbate 80 (Tween 80) is rapidly removed from systemic circulation. The polysorbate 80 plasma concentration-time curve (AUC) in a patient administered an intravenous (IV) infusion of docetaxel 35 mg/m2 (polysorbate 80 1.75 g) showed a polysorbate 80 peak concentration of 304 μg/ml. The AUC for polysorbate 80 was 321.7 mg h/ml, with a short disposition half-life of 1.07 h and a total plasma clearance of 5.44 l/h. The distribution of polysorbate 80 at steady state was similar to the total blood volume (4.16 l), suggesting that polysorbate 80 circulates as large micelles and does not significantly distribute outside the central compartment. In vitro studies suggest that polysorbate 80 is metabolized by rapid carboxylesterase-mediated hydrolysis[1].
Safety Profile
Moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Tween 80 Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 32 | 58 | Inquiry |
| ESTELLE CHEMICALS PVT LTD | +91-7620604545 +91-7620604545 | Maharashtra, India | 30 | 58 | Inquiry |
| JIVICHEM SYNTHESIS PVT LTD | +91-7028392790 +91-7028392790 | Maharashtra, India | 335 | 58 | Inquiry |
| CRYSTAL PHARMA | +91-9322218073 +91-9820141331 | Mumbai, India | 106 | 58 | Inquiry |
| VA SUDHA Chemicals Private Limited | +91-9653313056 +91-9653313056 | Maharashtra, India | 8 | 58 | Inquiry |
| HJ AROCHEM | +91-8690768060 +91-9724420086 | Ahmedabad, India | 171 | 58 | Inquiry |
| Akhil Healthcare Pvt Ltd | +91-8097372415 +91-8097372415 | Mumbai, India | 15 | 58 | Inquiry |
| Viswaat Chemicals Limited | +91-7208827711 +91-8291300373 | Mumbai, India | 63 | 58 | Inquiry |
| Gujarat Chemicals GUJCHEM | +91-9825114095 +91-9825114095 | Gujarat, India | 42 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Otto Chemie Pvt. Ltd. | 58 |
| ESTELLE CHEMICALS PVT LTD | 58 |
| JIVICHEM SYNTHESIS PVT LTD | 58 |
| CRYSTAL PHARMA | 58 |
| VA SUDHA Chemicals Private Limited | 58 |
| HJ AROCHEM | 58 |
| Akhil Healthcare Pvt Ltd | 58 |
| Viswaat Chemicals Limited | 58 |
| Gujarat Chemicals GUJCHEM | 58 |
| HRV Global Life Sciences | 58 |
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