Diethyl pyrocarbonate
- CAS No.
- 1609-47-8
- Chemical Name:
- Diethyl pyrocarbonate
- Synonyms
- DEPC;DIETHYL DICARBONATE;Ethyl pyrocarbonate;DKD;Piref;Baycovin;DEP／DEPC;DEPC/DEP;ethylpyrocarbonate;Diethylpyrokarbonat
- CBNumber:
- CB2300384
- Molecular Formula:
- C6H10O5
- Molecular Weight:
- 162.14
- MOL File:
- 1609-47-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 69℃ |
|---|---|
| Boiling point | 93-94 °C18 mm Hg(lit.) |
| Density | 1.12 g/mL at 20 °C |
| refractive index |
n |
| Flash point | 157 °F |
| storage temp. | 2-8°C |
| solubility | 95% ethanol: soluble4.5g/10 mL, clear, colorless |
| form | Liquid |
| color | APHA: ≤20 |
| biological source | synthetic (microbial fermentation/ cell culture) |
| Water Solubility | slow decomposition |
| Sensitive | Moisture Sensitive |
| Merck | 14,7998 |
| BRN | 637031 |
| Stability | Combustible. Unstable - readily decomposes. Incompatible with strong oxidizing agents, strong acids, strong reducing agents, strong bases, ammonia. |
| InChIKey | FFYPMLJYZAEMQB-UHFFFAOYSA-N |
| LogP | 1.101 (est) |
| CAS DataBase Reference | 1609-47-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Diethyl pyrocarbonate(1609-47-8) |
| EPA Substance Registry System | Dicarbonic acid, diethyl ester (1609-47-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LQ9350000 | |||||||||
| F | 4.4-9-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29209085 | |||||||||
| Toxicity | LD50 orally in Rabbit: 850 mg/kg | |||||||||
| NFPA 704 |
|
Diethyl pyrocarbonate price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D5758 | Diethyl pyrocarbonate 96% (NT) | 1609-47-8 | 5ML | ₹6094.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D5758 | Diethyl pyrocarbonate 96% (NT) | 1609-47-8 | 25ML | ₹17384.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D5758 | Diethyl pyrocarbonate 96% (NT) | 1609-47-8 | 100ML | ₹25482.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D5758 | Diethyl pyrocarbonate 96% (NT) | 1609-47-8 | 50ML | ₹31576.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 40718 | Diethyl pyrocarbonate 96% (NT) | 1609-47-8 | 5ML | ₹8075.45 | 2022-06-14 | Buy |
Diethyl pyrocarbonate Chemical Properties,Uses,Production
Chemical Properties
liquid
Uses
Diethyl pyrocarbonate may be used in the following studies:
- For the modification of histidyl residues in proteins.
- As a nuclease inhibitor, for the extraction of undegraded nucleic acids from etiolated and green plant tissues.
- For the modification of linear and supercoiled plasmid DNAs.
- As a chemical probe to investigate the secondary structure in negatively supercoiled DNA.
- For cabethoxylation of histidine residues of actin.
Definition
ChEBI: The diethyl ester of dicarbonic acid.
General Description
Diethyl pyrocarbonate (DEP) is a bactericidal agent and decomposes in water to CO2 and ethanol. DEP inhibits enzymes such as DNase and RNase without affecting nucleic acids. It is useful for the preparation of mRNA from tissues.
Safety Profile
Poison by ingestion, inhalation, and intraperitoneal routes. Concentrated DEPC is irritating to eyes, mucous membranes, and sh. When heated to decomposition it emits acrid smoke and fumes. See also ESTERS.
Purification Methods
Dissolve the ester in Et2O, wash it with dilute HCl, H2O, dry over Na2SO4, filter, evaporate and distil the residue first in vacuo then at atmospheric pressure. It is soluble in alcohols, esters, ketones and hydrocarbon solvents. A 50% w/w solution is usually prepared for general use. Treat with great CAUTION as DEP irritates the eyes, mucous membranes and skin. [Boehm & Mehta Chem Ber 71 1797 1938, Thoma & Rinke Justus Liebigs Ann Chem 624 30 1959, Beilstein 3 IV 18.]
Diethyl pyrocarbonate Preparation Products And Raw materials
Global( 405)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2683 | 50 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5870 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4315 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6157 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6088 | 58 | Inquiry |
| KIP Chemicals | 08048984391 | Mumbai, India | 20 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| SL Drugs and Pharmaceuticals Pvt. Ltd. | 50 |
| Otto Chemie Pvt. Ltd. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Central Drug House(P) Ltd. | 58 |
| Triveni chemicals | 58 |
| KIP Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
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