Dimethyl dicarbonate
- CAS No.
- 4525-33-1
- Chemical Name:
- Dimethyl dicarbonate
- Synonyms
- velcorin;DimethylDicarbonate(Dmdc);methylpyrocarbonate;DIMETHYL DICARBONATE;Rimonabant Impurity 1;DIMETHYL PYROCARBONATE;oxydi-formicacidimethylester;DICARBONIC ACID DIMETHYL ESTER;DIMETHYL DICARBONATE USP/EP/BP;Oxybis(formic acid methyl) ester
- CBNumber:
- CB9496174
- Molecular Formula:
- C4H6O5
- Molecular Weight:
- 134.09
- MOL File:
- 4525-33-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/3 9:27:12
| Melting point | 15-17°C |
|---|---|
| Boiling point | 45-46 °C5 mm Hg(lit.) |
| Density | 1.25 g/mL at 25 °C(lit.) |
| vapor pressure | 0.7 hPa (20 °C) |
| refractive index |
n |
| Flash point | 80 °C |
| storage temp. | Store below +30°C. |
| solubility | 35g/l (decomposition) |
| form | Oil |
| color | Colourless |
| explosive limit | 3-29.9%(V) |
| BRN | 956715 |
| Stability | Moisture Sensitive |
| LogP | 0.082 (est) |
| EPA Substance Registry System | Dicarbonic acid, dimethyl ester (4525-33-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H314-H330 |
| Precautionary statements | P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T |
| Risk Statements | 21/22-23-34 |
| Safety Statements | 18-26-28-36/37/39-38-45 |
| RIDADR | UN 2927 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | HT0362500 |
| F | 9-21 |
| Autoignition Temperature | 465 °C |
| HS Code | 2920 90 10 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | LD50 orally in Rabbit: 335 mg/kg LD50 dermal Rat > 1250 mg/kg |
Dimethyl dicarbonate Chemical Properties,Uses,Production
Chemical Properties
Dimethyl dicarbonate (DMDC) is a colourless liquid with a slightly pungent aroma. It is primarily used as a beverage preservative, processing aid, or sterilant (Enumber 242). The application of DMDC is particularly useful when wine needs to be sterilized but cannot be sterile filtered, pasteurized, or sulfured. DMDC is also used to stabilize non-alcoholic beverages such as carbonated or non-carbonated juice beverages, isotonic sports beverages, iced teas, and flavored waters.
Uses
Dimethyl Dicarbonate(DMDC) is a microbial control agent used in wine; ready-to-drink teas; nonjuice-containing beverages; carbonated,dilute beverages containing juice, fruit flavor or both with the juice content not exceeding 50%.
Dimethyl Dicarbonate has been commonly used as a antimicrobial agent for a broad spectrum of microorganisms. The primary target microorganisms of DMDC are yeasts, including Saccharomyces, Zygosaccharomyces, Rhodotorula, Candida, Pichia, Torulopsis, Torula, Endomyces, Kloeckera and Hansenula. DMDC is also bactericidal to a number of species including Acetobacter pasteurianus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, several Lactobacillus species and Pediococcus cerevisiae DMDC has also been shown to be bactericidal against Escherichia coli O157:H7.
The antimicrobial effect of DMDC results from the deactivation of microbial enzymes, mainly through reaction with protein imidazole and amine groups, leading to the destruction of the microorganisms. The remaining unreacted DMDC breaks down rapidly into methanol and carbon dioxide. The DMDC activity is based on the hydrolysis rate. Hydrolysis occurs when DMDC reacts with water and the rate is dependent on the temperature of the beverage or wine. It takes about four hours at 10°C (50°F) or two hours at 20°C (68°F) for DMDC completely breaking down.
Biochem/physiol Actions
Dimethyl dicarbonate (DMDC; Velcorin?) is a colourless liquid with an ester-like pungent odour. DMDC is soluble in water (3.65% solubility), aqueous solutions (e.g. beverages) and alcohol, where it is quickly hydrolysed. This hydrolysis is a quick process: 1 hour at 30°C and within 5 hours at 10°C. DMDC solidifies below 17 °C. It acts as a microbial control agent by inhibiting the enzymes acetate kinase and L-glutamic acid decarboxylase. DMDC undergoes hydrolyses in the presence of water to form primarily methanol and carbon dioxide, which are natural components of fruit and alcoholic drinks.
Purification Methods
Dissolve it in Et2O, shake this with a small volume of 0.1N HCl, dry Et2O with Na2SO4 and distil in in vacuo below 100o to give a clear liquid. It decomposes to CO2 and dimethyl carbonate on heating at 123-149o. It is readily hydrolysed by H2O and is a yeast inhibitor and an IRRITANT. [Brysov et al. J Org Chem USSR 10 2551 1974, Boehm & Mehta Chem Ber 71 1797 1938, Beilstein 3 IV 17.]
Dimethyl dicarbonate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| BLiT (Hefei)Chemical Co.,Ltd | +86-551-62622640 | China | 293 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12459 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 6011 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| airuikechemical co., ltd. | +undefined86-15315557071 | China | 983 | 58 | Inquiry |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +86-86177 | China | 2952 | 58 | Inquiry |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | China | 3002 | 58 | Inquiry |
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