Neostigmine Methyl Sulfate
- CAS No.
- 51-60-5
- Chemical Name:
- Neostigmine Methyl Sulfate
- Synonyms
- NEOSTIGMINE METHYL SULPHATE;neostigmine metilsulfate;hodostin;vagostigmin;NEOSTIGIMINE BROMIDE;3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE;GD-65;ar-32;sb-23;Stiglyn
- CBNumber:
- CB7853724
- Molecular Formula:
- C12H19N2O2.CH3O4S
- Molecular Weight:
- 334.39
- MOL File:
- 51-60-5.mol
- Modify Date:
- 2023/9/17 23:58:49
| Melting point | 175-177 °C(lit.) |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: 1 g/mL |
| form | powder |
| color | white |
| Water Solubility | 1g/10mL |
| Merck | 14,6464 |
| CAS DataBase Reference | 51-60-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H315-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P284-P301+P330+P331+P310-P304+P340-P305+P351+P338-P342+P311 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28-36/37/38-42/43-26/27/28 | |||||||||
| Safety Statements | 36-45-36/37/39-28A | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CY1225000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29242990 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 0.16 i.v.; 0.42 s.c.; 7.5 orally, (Randall, Lehmann) | |||||||||
| NFPA 704 |
|
Neostigmine Methyl Sulfate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N2126 | Neostigmine methyl sulfate | 51-60-5 | 500MG | ₹3712.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N2126 | Neostigmine methyl sulfate | 51-60-5 | 1G | ₹5921.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N2126 | Neostigmine methyl sulfate | 51-60-5 | 5G | ₹19214.38 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0447 | Neostigmine Methyl Sulfate | 51-60-5 | 5G | ₹8100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0447 | Neostigmine Methyl Sulfate | 51-60-5 | 25G | ₹17200 | 2022-05-26 | Buy |
Neostigmine Methyl Sulfate Chemical Properties,Uses,Production
Description
Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively). Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.
Chemical Properties
Crystalline Solid
Uses
Cholinergic; miotic; antidote (curare)
General Description
Neostigmine methylsulfate,(m-hydroxyphenyl)trimethylammonium methylsulfatedimethylcarbamate or the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniummethylsulfate (Prostigminmethylsulfate), is a bitter, odorless, white, crystalline powder.It is very soluble in water and soluble in alcohol. Solutionsare stable and can be sterilized by boiling. The compound istoo hygroscopic for use in a solid form and thus is alwaysused as an injection. Aqueous solutions are neutral to litmus.
Clinical Use
The methylsulfate salt is used postoperatively as a urinarystimulant and in the diagnosis and treatment of myastheniagravis.
Purification Methods
Crystallise the sulfate from EtOH or Me2CO (m 143-144o). Its solubility in H2O is ~10%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.)
Neostigmine Methyl Sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Vanquest Pharma Pvt Ltd | +91-9920897640 +91-9920897640 | Mumbai, India | 36 | 58 | Inquiry |
| Deccan Nutraceuticals Pvt. Ltd | +91-9822641298 +91-9822641298 | Mumbai, India | 18 | 58 | Inquiry |
| Indoco Remedies Ltd | +91-2262871000 +91-2262871000 | Gujarat, India | 27 | 58 | Inquiry |
| Harman Finochem Ltd | +91-2226528080 +91-2226528080 | Maharashtra, India | 37 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| Mac Chem Products (India) Pvt Ltd (Naprod Group) | +91-9727753234 +91-7770016606 | Maharashtra, India | 37 | 58 | Inquiry |
| Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd) | +91-2268107000 +91-9987232509 | Maharashtra, India | 30 | 58 | Inquiry |
| Enaltec Labs Pvt Ltd | +91-9167119247 +91-9167119247 | Maharashtra, India | 49 | 58 | Inquiry |
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