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4'-Bromo-3'-methylacetophenone

4'-Bromo-3'-methylacetophenone Structure
CAS No.
37074-40-1
Chemical Name:
4'-Bromo-3'-methylacetophenone
Synonyms
NSC 405623;Fluralaner-003;Fluralaner Impurity 29;3-Methyl-4-bromoacetophenone;4'-Bromo-3'-methylacetophenone;4'-BROMO-3'-METHYLACETOPHENONE;Ethanone, 1-(4-broMo-3-Methylphenyl)-
CBNumber:
CB7947102
Molecular Formula:
C9H9BrO
Molecular Weight:
213.07
MOL File:
37074-40-1.mol
MSDS File:
SDS
Modify Date:
2024/5/8 9:18:20
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4'-Bromo-3'-methylacetophenone Properties

Melting point 31-32 °C
Boiling point 157-159 °C(Press: 19 Torr)
Density 1.388±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form fused solid
color Pale lemon

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P271-P260-P280
HS Code  2914390090

4'-Bromo-3'-methylacetophenone Chemical Properties,Uses,Production

Uses

4'-Bromo-3'-methylacetophenone is a versatile building block that is used in the synthesis of many complex compounds. It can be used as a reactant, reagent, or speciality chemical.

Synthesis

A solution of 4-bromo-3-methylbenzaldehyde (4 g, 20 mmol) in dry tetrahydrofuran (40 mL) was cooled to 0??C under nitrogen atmosphere, and then methyl magnesium bromide (20 mL, 1N in tetrahydrofuran) was added dropwise. The ice bath was removed, and the mixture was stirred for 2 hours. Ammonium chloride aqueous (40 mL) was added and the mixture was extracted with dichloromethane (20 mL * 3). The organic phase was dried by sodium sulphate, filtered and concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate = 5:1) to give 1-(4-bromo-3-methylphenyl)ethanol. Colorless oil, yield 4.0 g, 93%. Pyridinium chlorochromate (48 g, 223 mmol) was added to a solution of 1-(4-bromo-3-methylphenyl)ethanol (31.9 g, 148 mmol) in dichloromethane (800 mL). The mixture was stirred at room temperature for 2 hours. The mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate = 25:1) to give 4'-Bromo-3'-methylacetophenone. Yield 27.3 g, 87%.
Synthesis_37074-40-1 Figure Synthesis of 4'-Bromo-3'-methylacetophenone

4'-Bromo-3'-methylacetophenone Preparation Products And Raw materials

Raw materials

Benzenemethanol, 4-bromo-α,3-dimethyl- N-(4-acetyl-2-methylphenyl)acetamide 4-Bromo-n-methoxy-n,3-dimethylbenzamide Ethanone, 1-(4-amino-3-methylphenyl)- (9CI) 4-BROMO-3-METHYL-BENZALDEHYDE
4-BROMO-3-METHYLBENZONITRILE 4-Bromo-3-methylbenzoic acid Methyllithium Acetyl chloride Methylmagnesium Bromide
2-METHYLACETANILIDE METHYLMAGNESIUM IODIDE
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Preparation Products

4-acetyl-2-methylbenzoic acid

4'-Bromo-3'-methylacetophenone Suppliers

Global( 99)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Ouhuang Engineering Materials (Hubei) Co., Ltd +86-86177 China 2952 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 16220 58 Inquiry
Fluoropharm Co., Ltd. +86-0571-85586753; +8613336034509 China 1377 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +86-19930503282 China 8828 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Shanghai Yingrui Biopharma Co.,Ltd 21-33585366 CHINA 1320 58 Inquiry
Allfluoro pharmaceutical co. ltd. 021-26137118 +8615821363818 China 5791 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Ouhuang Engineering Materials (Hubei) Co., Ltd 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
Fluoropharm Co., Ltd. 60
career henan chemical co 58
Hebei Guanlang Biotechnology Co., Ltd. 58
Chongqing Chemdad Co., Ltd 58
Shanghai Yingrui Biopharma Co.,Ltd 58
Allfluoro pharmaceutical co. ltd. 58

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Ethanone, 1-(4-broMo-3-Methylphenyl)- NSC 405623 3-Methyl-4-bromoacetophenone Fluralaner-003 4'-BROMO-3'-METHYLACETOPHENONE Fluralaner Impurity 29 4'-Bromo-3'-methylacetophenone 37074-40-1 Aromatic Acetophenones & Derivatives (substituted)