ROTIGOTINE
- CAS No.
- 99755-59-6
- Chemical Name:
- ROTIGOTINE
- Synonyms
- Neupro;N 0923;CS-110;SPM 962;Rotigotine;S(-)-N-0437;14C]-Rotigotine;Rotigotine (Base);Rotigotine (N-0437;ROTIGOTINE USP/EP/BP
- CBNumber:
- CB81001679
- Molecular Formula:
- C19H25NOS
- Molecular Weight:
- 315.47
- MOL File:
- 99755-59-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/20 14:19:32
| Melting point | 78 °C |
|---|---|
| Boiling point | 470.1±45.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| Water Solubility | Insoluble in water |
| solubility | DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml |
| pka | 10.49±0.40(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H336-H362-H361 |
| Precautionary statements | P261-P271-P304+P340-P312-P403+P233-P405-P501-P201-P202-P281-P308+P313-P405-P501-P201-P260-P263-P264-P270-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HS Code | 2934990002 |
ROTIGOTINE price More Price(2)
ROTIGOTINE Chemical Properties,Uses,Production
Description
While levodopa is still considered the cornerstone of treatment of Parkinson’s disease, many patients begin to experience treatment-related problems, such as a wearing-off phenomenon and the development of dyskinesias as the disease progresses. Continuous dopaminergic stimulation by means of a dopamine agonist has been recognized as being associated with a lower incidence of dyskinesias. Using a selective dopamine agonist as monotherapy in early disease may delay the onset of levodopa therapy, or at a minimum, lower its dose in adjunctive situations to minimize the adverse neurotoxic effects of levodopa. Rotigotine is a nonergolinic dopamine D3/D2/D1 receptor agonist, and it is the first dopamine agonist to be launched as a transdermal patch.
Uses
It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson disease.
General Description
Rotigotine, (6S)-6-{propyl[2-(2-thienyl)ethyl]amino}-5,6,7,8-tetrahydro-1-naphthalenol (Neupro),is a nonergoline that is available as a silicone-based, selfadhesivematrix, transdermal system for continuous delivery over a 24-hour period. Approximately 45% of the drug is releasedwithin 24 hours. The terminal half-life of rotigotine is5 to 7 hours after removal of the patch. Rotigotine is 90%bound to plasma proteins. The compound undergoes extensivemetabolism and has low bioavailability by the oralroute. The major metabolites of rotigotine are the glucuronideand sulfate conjugates of rotigotine and sulfateconjugates of N-despropylrotigotine and N-desthienylethylrotigotine. Rotigotine is excreted in the urine (71%) andfeces (11%).Studies using human liver microsomes didnot find any interactions with CYP1A2, CYP2C9,CYP2C19, CYP2D6, and CYP3A4 substrates.Rotigotinetransdermal system contains sodium metabisulfite, and individualssensitive to sulfite could be at risk for allergic reactions.Additionally, somnolence is a common adverse reactionwith individuals on rotigotine, and patients should beclosely monitored during therapy.In transfected Chinesehamster ovary (CHO) cells, rotigotine binds with high affinityat D3 and D2L receptors (variants in the D2 receptor subtypeare caused by insertion of the 29 amino acids into thethird loop to give D2s and D2L).Using rat CHO cells,rotigotine shows over 30-fold selectivity at D3 versus D2 receptors.48 Rotigotine was approved in May 2007 for thetreatment of early-stage PD.
ROTIGOTINE Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| Maithri Drugs Pvt Ltd | +91-9059204566 +91-9848881740 | Telangana, India | 64 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Anantco Enterprises Pvt., Ltd. | 91-22-67685000 | Maharashtra, India | 71 | 58 | Inquiry |
| Daga Global Chemicals Pvt., Ltd. (DGCPL) | 91-22-28920909 | Maharashtra, India | 14 | 58 | Inquiry |
| MYLAN LABORATORIES LIMITED | 040 -3086 6666 | New Delhi, India | 68 | 58 | Inquiry |
| Anika International Pvt. Limited | 91-11-47289900 | Delhi, India | 94 | 58 | Inquiry |
| Manus Aktteva Biopharma LLP | 08048250218Ext 800 | Ahmedabad, India | 655 | 58 | Inquiry |
| Oceanic Pharmachem Pvt. Ltd. | 91-22-42128600 | Maharashtra, India | 2006 | 58 | Inquiry |