Atipamezole hydrochloride
- CAS No.
- 104075-48-1
- Chemical Name:
- Atipamezole hydrochloride
- Synonyms
- Antisedan;Unii-2W4279571x;Atipamezole HCL;MPV1248 hydrochloride;MPV-1248 hydrochloride;MPV 1248 hydrochloride;Atipamezole hydrochloride;Atipamezole HCl (MPV-1248);Atipamezole hydrochloride, >=99%;4-(2-ethylindan-2-yl)-1H-imidazole
- CBNumber:
- CB81210097
- Molecular Formula:
- C14H16N2.HCl
- Molecular Weight:
- 248.75
- MOL File:
- 104075-48-1.mol
- Modify Date:
- 2024/11/19 23:02:33
| Melting point | 211-215° |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,861 |
| InChI | InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H |
| InChIKey | PCCVCJAQMHDWJY-UHFFFAOYSA-N |
| SMILES | C1(CC)(CC2=C(C=CC=C2)C1)C1=CNC=N1.Cl |
| CAS DataBase Reference | 104075-48-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332-H312-H302 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 | |||||||||
| RTECS | NI6139000 | |||||||||
| HS Code | 2933.29.2000 | |||||||||
| Toxicity | LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin) | |||||||||
| NFPA 704 |
|
Atipamezole hydrochloride price More Price(2)
Atipamezole hydrochloride Chemical Properties,Uses,Production
Biological Activity
Selective α 2 -adrenergic receptor antagonist (K i values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α 2A , α 2B , α 2C , α 1A and α 1B receptors respectively). Brain penetrant.
Side effects
A transient hypotensive effect has been observed during the first 10 minutes post-injection of atipamezole hydrochloride. In rare cases, hyperactivity, tachycardia, salivation, atypical vocalization, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination, and defecation may occur. In very rare cases, recurrence of sedation may occur, or the recovery time may not be shortened after administration of atipamezole. In cats, when using low doses to reverse the effects of medetomidine or dexmedetomidine partially, the possibility of hypothermia (even when aroused from sedation) should be guarded against.
Veterinary Drugs and Treatments
Atipamezole is labeled for use as a reversal agent for medetomidine and dexmedetomidine. It potentially could be useful for reversal of other alpha2-adrenergic agonists as well (e.g., amitraz, xylazine, clonidine, tizanidine, brimonidine).
Atipamezole hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4217 | 58 | Inquiry |
| Cipla Limited | 08048372510Ext 768 | Pune, India | 27 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3887 | 58 | Inquiry |
| Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 | China | 151 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5889 | 58 | Inquiry |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | China | 1010 | 58 | Inquiry |
| airuikechemical co., ltd. | +86-18353166132 +86-18353166132 | China | 983 | 58 | Inquiry |
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