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napyradiomycin A1

napyradiomycin A1 Structure
CAS No.
103106-24-7
Chemical Name:
napyradiomycin A1
Synonyms
WS-9558A;Napyradiomycin A;napyradiomycin A1;3,4a-Dichloro-6,8-dihydroxy-3,4,4a,10a-tetrahydro-2,2-dimethyl-10a-(3,7-dimethyl-2,6-octadienyl)-2H-naphtho[2,3-b]pyran-5,10-dione;2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-10a-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2-dimethyl-, (3R,4aR,10aS)-
CBNumber:
CB81373343
Molecular Formula:
C25H30Cl2O5
Molecular Weight:
481.41
MOL File:
103106-24-7.mol
Modify Date:
2023/7/14 17:43:52
Request For Quotation

napyradiomycin A1 Properties

Boiling point 642.5±55.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
form A solid
pka 6.14±0.70(Predicted)

SAFETY

Risk and Safety Statements

HS Code  29419000
Toxicity mouse,LD50,intraperitoneal,> 250mg/kg (250mg/kg),Journal of Antibiotics. Vol. 39, Pg. 487, 1986.

napyradiomycin A1 Chemical Properties,Uses,Production

Description

Napyradiomycin A1 is a fungal metabolite originally isolated from C. rubra and has diverse biological activities. It is active against S. aureus, M. luteus, B. anthracis, C. bovis, and M. smegmatis (MICs = 1.56-12.5 μg/ml). Napyradiomycin A1 is an estrogen receptor antagonist (IC50 = 4.2 μM in rat uterine homogenates). It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM, respectively).

Uses

Napyradiomycin derivatives have antibacterial and tumor properties. Napyradiomycin A1 is a secondary metabolite isolated from Streptomyces. It is also an antibacterial antibiotic and an inhibitor of mitochondrial complexes I and II.

napyradiomycin A1 Preparation Products And Raw materials

Raw materials

Preparation Products

napyradiomycin A1 Suppliers

Global( 10)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
cfm Oskar Tropitzsch +49 9231961928 Germany 1136 62 Inquiry
Apollo Scientific Ltd. 44 161 406 0505 United Kingdom 6097 88 Inquiry
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 China 11289 58 Inquiry
Zhejiang Huida Biotech Co., LTD 0571-0571-89903882 15990081639 China 3705 58 Inquiry
Zhejiang Huida Biotech Co., LTD 0571-89903882 13626641628 China 3656 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8740 58 Inquiry
BOC Sciences 1-631-485-4226; 16314854226 United States 14059 65 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28118 58 Inquiry
Supplier Advantage
cfm Oskar Tropitzsch 62
Apollo Scientific Ltd. 88
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Zhejiang Huida Biotech Co., LTD 58
Zhejiang Huida Biotech Co., LTD 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
BOC Sciences 65
TargetMol Chemicals Inc. 58

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napyradiomycin A1 3,4a-Dichloro-6,8-dihydroxy-3,4,4a,10a-tetrahydro-2,2-dimethyl-10a-(3,7-dimethyl-2,6-octadienyl)-2H-naphtho[2,3-b]pyran-5,10-dione Napyradiomycin A WS-9558A 2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-10a-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2-dimethyl-, (3R,4aR,10aS)- 103106-24-7 C25H30Cl2O5 Antibiotic