2-CHLORO-4'-HYDROXYACETOPHENONE

2-CHLORO-4'-HYDROXYACETOPHENONE Structure
CAS No.
6305-04-0
Chemical Name:
2-CHLORO-4'-HYDROXYACETOPHENONE
Synonyms
Brn 2086326;chlorophenacyle;Einecs 228-613-0;p-(chloroacetyl)phenol;Isoproterenol Impurity 3;4-hydroxyphenacylchloride;Isoproterenol Impurity 1;P- HYDROXY PHENACYL CHLORIDE;2-Chloro-1-(4-hydroxyphenyl);α-Chloro-p-hydroxyacetophenone
CBNumber:
CB1512120
Molecular Formula:
C8H7ClO2
Molecular Weight:
170.59
MOL File:
6305-04-0.mol
MSDS File:
SDS
Modify Date:
2023/8/14 17:23:18

2-CHLORO-4'-HYDROXYACETOPHENONE Properties

Melting point 145-146 °C
Boiling point 241.44°C (rough estimate)
Density 1.2315 (rough estimate)
refractive index 1.5100 (estimate)
pka 7.72±0.15(Predicted)
CAS DataBase Reference 6305-04-0(CAS DataBase Reference)
EPA Substance Registry System Ethanone, 2-chloro-1-(4-hydroxyphenyl)- (6305-04-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  2914790090

2-CHLORO-4'-HYDROXYACETOPHENONE Chemical Properties,Uses,Production

Uses

2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity.

Preparation

Also obtained by reaction of acetyl chloride with anisole in the presence of aluminium chloride in n-heptane at 35° for 4 h 30 min (20%).

2-CHLORO-4'-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-hydroxyphenacylchloride chlorophenacyle p-(chloroacetyl)phenol 2-Chloro-1-(4-hydroxy-phenyl)ethanone Acetophenone, 2-chloro-4'-hydroxy- Brn 2086326 Einecs 228-613-0 Ethanone, 2-chloro-1-(4-hydroxyphenyl)- 2-Bhloro-4'- hydroxyacetophenone P- HYDROXY PHENACYL CHLORIDE 2-chloro-1-(4-hydroxyphenyl)ethan-1-one 4'-Hydroxy-α-chloroacetophenone α-Chloro-4'-hydroxyacetophenone α-Chloro-p-hydroxyacetophenone 2-Chloro-4'-hydroxyacetophenone 2-chloro-1-(4-hydroxyphenyl)-ethanon 2-chloro-4’-hydroxy-acetophenon 2-Chloro-1-(4-hydroxyphenyl) Isoproterenol Impurity 1 (2S)-2-amino-3-[4-(4-hydroxyphenoxy)-3-iodophenyl]propanoic acid Isoproterenol Impurity 3 2-c2-chloro-1-(4-hydroxyphenyl)ethan-1-onehloro-1-(4-hydroxyphenyl)ethan-1-one 2-chloro-4'-hydroxyacetophenone 6305-04-0