SECURININE
- CAS No.
- 5610-40-2
- Chemical Name:
- SECURININE
- Synonyms
- securinin;SECURININE;Securan one;(-)-securinin;(-)-Securinin;SECURAN-11-ONE;SECURININE(RG);(-)-SECURININE;(–)-Securinine;Securinan-11-on
- CBNumber:
- CB8247560
- Molecular Formula:
- C13H15NO2
- Molecular Weight:
- 217.26
- MOL File:
- 5610-40-2.mol
- Modify Date:
- 2023/9/20 16:43:00
| Melting point | 140-1420C |
|---|---|
| alpha | D20 -1042° (c = 1 in alc) |
| Boiling point | 357.82°C (rough estimate) |
| Density | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: ≥25mg/mL |
| form | powder |
| pka | 8.29±0.20(Predicted) |
| color | yellow |
| optical activity | [α]/D -980 to -1015 (C=1, MeOH) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 23/24/25-22 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VS4115000 | |||||||||
| NFPA 704 |
|
SECURININE Chemical Properties,Uses,Production
Description
A constituent of the leaves of Securinega suffructicosa Rehd., the base also occurs in Phyllanthus disco ides. It is obtained as yellow crystals and is strongly laevorotatory having [α]20D - 1106°(CHC13), [α]30D - 1106°(CHC13) and[α]20D - 1042° (c 1.0, EtOH). The alkaloid yields a crystalline methiodide, m.p. 235-6°C.
Chemical Properties
Yellow Solid
Uses
Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity.
References
Murav'eva, Ban'kovskii., Dokl. Akad. Nauk, SSSR, 110,998 (1956)
Saito et al., Chem. & Ind., 1652 (1962)
Satoda et al., Tetrahedron Lett., 1199 (1962)
Mukherjee et al., Naturwiss., 50, 155 (1963)
Nakano et aI., Chem. & Ind., 1763 (1963)
Horii et al., ibid, 664 (1964)
Bevan et aI., ibid, 838 (1964)
Absolute configuration:
Bevan et al., Chern. Ind., 838 (1964)
Imadoetal., ibid, 1691 (1964)
Synthesis:
Horii et al., Tetrahedron, 23, 2265 (1967)
SECURININE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 12210 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26216 | 58 | Inquiry |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | CHINA | 9427 | 58 | Inquiry |
| changzhou huayang technology co., ltd | +8615250961469 | China | 9821 | 58 | Inquiry |
| Hebei baicao biology science and technology co., ltd | +86-19131911055 +8617824879454 | China | 1035 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
5610-40-2(SECURININE)Related Search:
1of4
chevron_right