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(R)-(-)-1,2-Propanediol

CAS No.: 4254-14-2

Chemical Name:: (R)-(-)-1,2-Propanediol

Synonyms: (R)-propane-1,2-diol;(R)-1,2-PROPANEDIOL;R-1,2-PD;(R)-1,2-propandiol;(R)-(-)-PROPANEDIOL;(2R)-1,2-Propanediol;(2R)-PROPANE-1,2-DIOL;(R)-(-)-1,2-PROPANEDIOL;(R)-(-)-PROPYLENE GLYCOL;Intermediate For Tenofovir

CBNumber:: CB8249625

Molecular Formula:: C3H8O2

Molecular Weight:: 76.09

MOL File:: 4254-14-2.mol

MSDS File:: SDS

Modify Date:: 2024/1/23 14:06:52

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(R)-(-)-1,2-Propanediol Properties

Melting point	-57C
alpha	-17 º (c=neat)
Boiling point	186-188 °C765 mm Hg(lit.)
Density	1.04 g/mL at 25 °C(lit.)
refractive index	n20/D 1.434(lit.)
Flash point	225 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Miscible with acetone, chloroform, ethanol (95%), glycerin, and water; soluble at 1 in 6 parts of ether; not miscible with light mineral oil or fixed oils, but will dissolve some essential oils.
pka	14.49±0.20(Predicted)
form	clear liquid
color	Colorless to Light orange to Yellow
Specific Gravity	1.036
optical activity	[α]20/D 16.5°, neat
Sensitive	Hygroscopic
Merck	14,7855
BRN	1718872
CAS DataBase Reference	4254-14-2(CAS DataBase Reference)
NIST Chemistry Reference	R-(-)-1,2-propanediol(4254-14-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P264-P280-P305+P351+P338+P337+P313

Hazard Codes

F,Xn

Risk Statements

20-65-15-10

Safety Statements

24/25-43-7/8

WGK Germany

HS Code

29053200

NFPA 704

	1
0		1

(R)-(-)-1,2-Propanediol price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	540242	(R)-(−)-1,2-Propanediol 96%	4254-14-2	5G	₹16313.28	2022-06-14	Buy
Sigma-Aldrich(India)	540242	(R)-(−)-1,2-Propanediol 96%	4254-14-2	5G	₹16313.28	2022-06-14	Buy
Sigma-Aldrich	540242	(R)-(−)-1,2-Propanediol 96%	4254-14-2	25G	₹30212.58	2022-06-14	Buy
Sigma-Aldrich(India)	540242	(R)-(−)-1,2-Propanediol 96%	4254-14-2	25G	₹30212.58	2022-06-14	Buy
ALFA India	ALF-B21937-14	(R)-(-)-1,2-Propanediol, 98%	4254-14-2	25g	₹28608	2022-05-26	Buy

Product number	Packaging	Price	Buy
540242	5G	₹16313.28	Buy
540242	5G	₹16313.28	Buy
540242	25G	₹30212.58	Buy
540242	25G	₹30212.58	Buy
ALF-B21937-14	25g	₹28608	Buy

(R)-(-)-1,2-Propanediol Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liqui

Uses

R-(-)-1,2-Propanediol, is a chiral building blocks that can be used for variety of chemical synthesis.

Production Methods

Propylene is converted to chlorohydrin by chlorine water and hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2- propylene oxide is converted to propylene glycol.

Pharmaceutical Applications

Propylene glycol has become widely used as a solvent, extractant, and preservative in a variety of parenteral and nonparenteral pharmaceutical formulations. It is a better general solvent than glycerin and dissolves a wide variety of materials, such as corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is similar to glycerin and only slightly less effective than ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film-coating formulations.
Propylene glycol is also used in cosmetics and in the food industry as a carrier for emulsifiers and as a vehicle for flavors in preference to ethanol, since its lack of volatility provides a more uniform flavor.

storage

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed container, protected from light, in a cool, dry place.

Incompatibilities

Propylene glycol is incompatible with oxidizing reagents such as potassium permanganate.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; inhalations; ophthalmic, oral, otic, percutaneous, rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

(R)-(-)-1,2-Propanediol Preparation Products And Raw materials

Raw materials

(S)-(-)-Propylene oxide (R)-(+)-Propylene oxide Propylene oxide Chlorine PROPYLENE

Preparation Products

(S)-(+)-1,2-Propanediol

(R)-(-)-1,2-Propanediol Suppliers

Global( 302)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry
CAD Pharma Inc.	91-80-41536439	Karnataka, India	123	58	Inquiry
Atlanta Associates	08048372939Ext 940	Mumbai, India	184	58	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20313	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16216	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
Alfa Aesar	58
CAD Pharma Inc.	58
Atlanta Associates	58
CHEMSWORTH	30
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58

4254-14-2((R)-(-)-1,2-Propanediol)Related Search:

2-METHYL-1,3-PROPANEDIOL Poly(propylene glycol) Propylene oxide Glycerol 1,4-Butanediol

PROPYLENE 3-Amino-1,2-propanediol Dipropylene glycol 1-Methoxy-2-propyl acetate 1-Methoxy-2-propanol

Diethylene glycol Propylene glycol Ethylene glycol diacetate Ethylene glycol 2-Butoxyethanol

1,3-Propanediol 2-Methyl-2,4-pentanediol Tenofovir

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(2R)-PROPANE-1,2-DIOL (R)-(-)-PROPYLENE GLYCEROL (R)-(-)-PROPYLENE GLYCOL (R)-(-)-PROPANEDIOL (R)-(-)-1,2-Propyleneglycol (R)-(-)-1,2-PROPANEDIOL (R)-(-)-1,2-DIHYDROXYPROPANE (R)-1,2-propandiol (R-(--1,2-Propanediol))-IntermediateForTenofovir Intermediate For Tenofovir (R)-(-)-1,2-Propanediol,98% (R)-(-)-1,2-Propanediol 4254-14-2 (R)-(-)-Propylene glycerol, (R)-(-)-Propylene glycol (2R)-1,2-Propanediol R-1,2-PD R-(-)-1,2-PROPANEDIOL / R-(-)-PROPYLENEGLYCEROL (R)-(-)-1,2-Propanediol,96% (R)-(-)-1,2-Propanediol, 99%, ee: 98% (R)-(-)-1,2-Propanediol, ee: 98% (R)-(-)-1,2-Dihydroxypropane (R)-(-)-Propylene Glycol (R)-(-)-1,2-Propanediol 96% 1,2-Propanediol, (R)- (9CI) (R)-(-)-1,2-Propanediol> (R)-propane-1,2-diol (R)-1,2-PROPANEDIOL Tenofovir disoproxil Impurity 93 4254-14-2 CH2OHCHOHCH3 HOCH2CH2CH2OH CH3CHOHCH2OH Organic Building Blocks Polyols Asymmetric Synthesis Simple Alcohols (Chiral) Chiral Building Blocks chiral Chiral Building Blocks Simple Alcohols (Chiral) Synthetic Organic Chemistry Chiral Compounds Diols