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N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide Structure
CAS No.
893990-34-6
Chemical Name:
N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
Synonyms
CS-1198;VU 0240551;CID 7211972;VU0240551-1;SID 56405457;VU0240551-2-D4;N-(4-Methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetaMide;N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide;Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-;N-(4-Methyl-thiazol-2-yl)-2-(6-phenyl-pyridazin-3-ylsulfanyl)-acetamide
CBNumber:
CB82518969
Molecular Formula:
C16H14N4OS2
Molecular Weight:
342.44
MOL File:
893990-34-6.mol
MSDS File:
SDS
Modify Date:
2024/10/30 20:13:01
Request For Quotation

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide Properties

Melting point 127 - 132°C
Density 1.39±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
form powder
pka 7.59±0.50(Predicted)
color Pale Beige to Beige

SAFETY

Risk and Safety Statements

WGK Germany  3

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) V3890 VU0240551 ≥98% (HPLC) 893990-34-6 5MG ₹22894.88 2022-06-14 Buy
Product number Packaging Price Buy
V3890 5MG ₹22894.88 Buy

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide Chemical Properties,Uses,Production

Description

VU0240551 is a K+/Cl- cotransporter 2 (KCC2) inhibitor (IC50 = 568 nM). It selectively inhibits KCC2 over Na+/K+/Cl- cotransporter 1 (NKCC1; IC50 = >50 μM) but does inhibit the activity of adenosine A1 and A3 receptors, as well as inhibits activity of L-type calcium channels at the benzothiazepine site and human ether-a-go-go-related gene (hERG) potassium channels by greater than 50% in a panel of 68 receptors, ion channels, and transporters at 10 μM. VU0240551 decreases potassium ion uptake by 70% in HEK293 cells expressing KCC2 when used at a concentration of 1 μM.

Biochem/physiol Actions

VU0240551 is a potent, selective KCC2 inhibitor. KCC2 is a potassium-chloride exchanger expressed specifically in neurons. KCC2 functions to lower intracellular chloride concentrations below the electrochemical potential of the cells, thereby increasing the hyperexcitability of the neurons. KCC2 activity enhances GABA and other inhibitory neurotransmission and is implicated in pain processing. VU0240551 was discovered in a high-throughput screen, followed by directed medicinal chemistry. VU0240551 is selective for KCC2 over NKCC1. VU0240551 binds competitively to the K+ site and binds noncompetitively to the Cl- site. VU0240551 is the only small molecule with specificity for a KCC family member.

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide Suppliers

Global( 57)Suppliers
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ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32951 60 Inquiry
TargetMol Chemicals Inc. United States 38463 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131957 58 Inquiry
Shanghai Ziqi Biological Technology Co., Ltd. 400-811-9081 13681619662 CHINA 6184 58 Inquiry
Shanghai Weiwei Biological Technology Co., Ltd. 021-55669583 18616258598 CHINA 4398 58 Inquiry
Shanghai Jinsui Biological Technology Co., Ltd. 021-60488140 13916773654 CHINA 108 58 Inquiry
Shanghai Haoyang Biological Technology Co., Ltd. 021-54046790 15121098156 CHINA 2905 58 Inquiry
Shanghai Machine Pure Industrial Co., Ltd. 021-54720761 13524933993 CHINA 6800 58 Inquiry
Shanghai Yuda Industrial Co., Ltd. 021-64133189 13788995069 CHINA 6105 58 Inquiry
Shanghai Lianshuobao is Biotechnology Co., Ltd. 400-0918-500 CHINA 6984 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
Amadis Chemical Company Limited 58
Shanghai Ziqi Biological Technology Co., Ltd. 58
Shanghai Weiwei Biological Technology Co., Ltd. 58
Shanghai Jinsui Biological Technology Co., Ltd. 58
Shanghai Haoyang Biological Technology Co., Ltd. 58
Shanghai Machine Pure Industrial Co., Ltd. 58
Shanghai Yuda Industrial Co., Ltd. 58
Shanghai Lianshuobao is Biotechnology Co., Ltd. 58

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N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide VU 0240551 N-(4-Methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetaMide CID 7211972 SID 56405457 VU0240551-1 VU0240551-2-D4 N-(4-Methyl-thiazol-2-yl)-2-(6-phenyl-pyridazin-3-ylsulfanyl)-acetamide CS-1198 Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- 893990-34-6