Chinese english Japanese Germany Korea

VU 0360223

VU 0360223 Structure
CAS No.
1274859-33-4
Chemical Name:
VU 0360223
Synonyms
VU 0360223;3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile;Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)-;3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile
CBNumber:
CB22569686
Molecular Formula:
C15H9FN2S
Molecular Weight:
268.31
MOL File:
1274859-33-4.mol
Modify Date:
2024/10/28 16:48:35
Request For Quotation

VU 0360223 Properties

Boiling point 434.9±35.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility Soluble to 25 mM in DMSO
form Powder
pka 1.10±0.10(Predicted)

VU 0360223 Chemical Properties,Uses,Production

Description

Glutamate, the major excitatory neurotransmitter in the central nervous system, signals through both ionotropic and metabotropic glutamate receptors. Of the eight metabotropic glutamate receptors (mGlus) discovered thus far, development of inhibitors to mGlu5 has been given significant attention in preclinical models of disease, including pain, anxiety, gastresophageal reflux disease, Parkinson’s associated dyskinesia, and fragile X syndrome, as well as in animal models of drug addiction. VU0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 that demonstrates an IC50 value of 61 nM in a calcium mobilization assay and a Ki value of 477 nM in a radioligand binding assay. A 10 μM concentration of VU0360223 results in a near complete blockade of the glutamate response in cortical astrocytes. A 30 mg/kg dose of VU0360223 in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.

Uses

VU 0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 for use in drug addiction treatment.

VU 0360223 Preparation Products And Raw materials

Raw materials

Preparation Products

VU 0360223 Suppliers

Global( 38)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32063 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57505 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48461 58 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9806 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24648 58 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5726 77 Inquiry
ApexBio Technology + 1-832-696-8203 United States 6251 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6650 58 Inquiry
Beijing Fubo Biotechnology Co., Ltd. 010-57263844 13260236521 CHINA 6025 58 Inquiry
Beijing Shengke Boyuan Biotechnology Co., Ltd. 010-62968438 CHINA 6005 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Tocris Bioscience 77
ApexBio Technology 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
Beijing Fubo Biotechnology Co., Ltd. 58
Beijing Shengke Boyuan Biotechnology Co., Ltd. 58

1274859-33-4(VU 0360223)Related Search:

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide VU0134992(hydrochloride) VU6005649 VU 591 hydrochloride VU0810464
VU0483605 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VU 6008667 (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide
5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine VU 0360172 VU 0365114 VU 0357121
VU 0364439 VU0650786 VU0661013
chevron_left

1of4

chevron_right
VU 0360223 3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile 3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)- 1274859-33-4