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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Protein tyrosine kinase /JAK / STAT >JAK inhibitors >WP1066

WP1066

WP1066 Structure
CAS No.
857064-38-1
Chemical Name:
WP1066
Synonyms
WP1066;CS-604;WP1066, >=99%;WP1066/WP-1066;WP1066 USP/EP/BP;STAT Inhibitor III;WP1066 (DMSO solution);WP1066; WP 1066;WP-1066;wp1066(STAT Inhibitor III);Stat3 Inhibitor III, WP1066
CBNumber:
CB82616030
Molecular Formula:
C17H14BrN3O
Molecular Weight:
356.22
MOL File:
857064-38-1.mol
MSDS File:
SDS
Modify Date:
2023/7/12 16:53:24
Request For Quotation

WP1066 Properties

Melting point 90-93oC
Boiling point 569.9±50.0 °C(Predicted)
Density 1.425
storage temp. +2C to +8C
solubility Soluble in DMSO (up to at least 25 mg/ml)
form Off-white solid
pka 11.00±0.46(Predicted)
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29333990
NFPA 704
0
2 0

WP1066 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 573097 STAT3 Inhibitor III, WP1066 STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor 857064-38-1 10MG ₹22910 2022-06-14 Buy
Product number Packaging Price Buy
573097 10MG ₹22910 Buy

WP1066 Chemical Properties,Uses,Production

Description

WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 μM. It also induces apoptosis in U87-MG (IC50 = 5.6 μM) and U373-MG (IC50 = 3.7 μM) cells. WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats.

Uses

WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells.

WP1066 Preparation Products And Raw materials

Raw materials

2-cyano-N-((S)-1-phenylethyl)acetamide 6-Bromopyridine-2-carbaldehyde

Preparation Products

WP1066 Suppliers

Global( 136)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29888 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24200 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58

WP1066 Spectrum

WP1066(857064-38-1)1HNMR

857064-38-1(WP1066)Related Search:

2-Bromopyridine 2-Amino-4-bromopyridine 2-Chloro-4-bromopyridine 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide WP1130
(2E)-3-(4'-Hydroxy-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl)-2-propenoic acid Pracinostat BAY 11-7085 ML264 Selumetinib
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LFM-A13 Brefeldin A 4-BROMOPYRIDINE
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WP1066 (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP1066/WP-1066 (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP 1066 WP1066, >=99% wp1066(STAT Inhibitor III) Stat3 Inhibitor III, WP1066 (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide WP1066 USP/EP/BP WP1066, 98%, a novel inhibitor of JAK2 and STAT3 CS-604 WP1066; WP 1066;WP-1066 STAT Inhibitor III 2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-, (2E)- WP-1066 STAT3 Inhibitor III WP1066 WP1066 (DMSO solution) (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide , WP1066 857064-38-1 C17H14ON3Br Inhibitors JAK STAT Inhibitor API