MI-136

CAS No.: 1628316-74-4

Chemical Name:: MI-136

Synonyms: MI-136;CS-2162;MI136;MI 136;HY-19319 (MI 136;MI-136;HY-19319 (MI 136; MI136);;5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-in;5-[[4-[[6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile;1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-;PPI,MI 136,Apoptosis,inhibit,MI136,Inhibitor,CRPC,castration,cancer,resistant,MI-136,Androgen Receptor,Epigenetic Reader Domain,prostate

CBNumber:: CB83121119

Molecular Formula:: C23H21F3N6S

Molecular Weight:: 470.51

MOL File:: 1628316-74-4.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:24

Request For Quotation

MI-136 Properties

Boiling point	654.9±55.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 10 mg/ml
form	A crystalline solid
pka	14.20±0.30(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

NFPA 704

	0
2		0

MI-136 Chemical Properties,Uses,Production

Description

MI-136 is an inhibitor of the menin-MLL interaction (IC₅₀ = 31 nM; K_d = 23.6 nM). By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of castration-resistant tumors in mice.

MI-136 Preparation Products And Raw materials

Raw materials

Preparation Products

MI-136 Suppliers

Global( 65)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	China	42057	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	China	4695	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Amadis Chemical Company Limited	58

1628316-74-4(MI-136)Related Search:

SAR405838 (MI-773) MI-3 (Menin-MLL Inhibitor) MI-2 (Menin-MLL Inhibitor) CeftazidiMe

MI-136 MI-136;HY-19319 (MI 136; MI136); HY-19319 (MI 136 1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]- 5-[[4-[[6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile 5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-in MI136;MI 136 CS-2162 PPI,MI 136,Apoptosis,inhibit,MI136,Inhibitor,CRPC,castration,cancer,resistant,MI-136,Androgen Receptor,Epigenetic Reader Domain,prostate 1628316-74-4 C23H21F3N6S