ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Histone Methyltransferase Inhibitors >MI-3 (Menin-MLL Inhibitor)

MI-3 (Menin-MLL Inhibitor)

CAS No.: 1271738-59-0

Chemical Name:: MI-3 (Menin-MLL Inhibitor)

Synonyms: MI-3;CS-1809;5-dihydro-5;Menin-MLL inhibitor 3;MI-3 (Menin-MLL Inhibitor);MI-3 (Menin-MLL Inhibitor) USP/EP/BP;5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl);MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor;4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine;Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-

CBNumber:: CB42624233

Molecular Formula:: C18H25N5S2

Molecular Weight:: 375.55

MOL File:: 1271738-59-0.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:08

Request For Quotation

MI-3 (Menin-MLL Inhibitor) Properties

Boiling point	527.9±60.0 °C(Predicted)
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic)
form	Powder
pka	9.59±0.40(Predicted)
color	Light yellow to yellow

MI-3 (Menin-MLL Inhibitor) Chemical Properties,Uses,Production

Description

MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC₅₀ = 648 nM). MI-3 binds to menin (K_d = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC₅₀ = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.

Uses

MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.

MI-3 (Menin-MLL Inhibitor) Preparation Products And Raw materials

Raw materials

Preparation Products

MI-3 (Menin-MLL Inhibitor) Suppliers

Global( 81)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24639	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	China	892	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	China	4695	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry

Supplier	Advantage
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Amadis Chemical Company Limited	58

1271738-59-0(MI-3 (Menin-MLL Inhibitor))Related Search:

MI-136 SAR405838 (MI-773) MI-2 (Menin-MLL Inhibitor) Tazemetostat (EPZ-6438) ACY-1215

Panobinostat (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol I-BET-762 OG-L002

chevron_left

1of2

chevron_right

MI-3 Menin-MLL inhibitor 3 Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)- 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3 (Menin-MLL Inhibitor) 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3 5-dihydro-5 5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl) MI3;MI 3;MENIN-MLL INHIBITOR 3;THIENO[2;3-D]PYRIMIDINE; 4-[4-(4;5-DIHYDRO-5;5-DIMETHYL-2-THIAZOLYL)-1-PIPERAZINYL]-6-(1-METHYLETHYL) CS-1809 MI-3 (Menin-MLL Inhibitor) USP/EP/BP MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor 1271738-59-0 Inhibitors