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RET Kinase inhibitor 1

RET Kinase inhibitor 1 Structure
CAS No.
1627856-64-7
Chemical Name:
RET Kinase inhibitor 1
Synonyms
CS-2597;GSK3179106;GSK-3179106;RET Kinase inhibitor 1;c-RET inhibitor GS3179106;Benzeneacetamide, 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-;syndrome,post-inflammatory,visceral,stress-induced,irritable,RET,Inhibitor,bowel,hypersensitivity,orally,GSK 3179106,inhibit,IBS,GSK3179106,GSK-3179106
CBNumber:
CB83356171
Molecular Formula:
C22H21F4N3O4
Molecular Weight:
467.41
MOL File:
1627856-64-7.mol
Modify Date:
2024/7/2 8:55:27
Request For Quotation

RET Kinase inhibitor 1 Properties

Boiling point 670.1±55.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:81.0(Max Conc. mg/mL);173.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:15.5(Max Conc. mg/mL);33.16(Max Conc. mM)
form A crystalline solid
pka 10.30±0.10(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
NFPA 704
0
2 0

RET Kinase inhibitor 1 Chemical Properties,Uses,Production

Description

GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC50 = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC50 = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.

RET Kinase inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

RET Kinase inhibitor 1 Suppliers

Global( 56)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Boao Pike 010-57798038 15652371397 CHINA 6629 58 Inquiry
Beijing Bolide Biotechnology Co., Ltd. 010-51653916 CHINA 6172 58 Inquiry
Shanghai Machine Pure Industrial Co., Ltd. 021-54720761 13524933993 CHINA 6800 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Boao Pike 58
Beijing Bolide Biotechnology Co., Ltd. 58
Shanghai Machine Pure Industrial Co., Ltd. 58

1627856-64-7(RET Kinase inhibitor 1)Related Search:

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide GSK484 GSK583 GSK369796 GSK461364
GSK547 GSK-467 GSK481 GSK-3326595 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
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RET Kinase inhibitor 1 CS-2597 c-RET inhibitor GS3179106 GSK3179106 GSK-3179106 Benzeneacetamide, 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]- syndrome,post-inflammatory,visceral,stress-induced,irritable,RET,Inhibitor,bowel,hypersensitivity,orally,GSK 3179106,inhibit,IBS,GSK3179106,GSK-3179106 1627856-64-7 C22H21F4N3O4