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E-4031

E-4031 Structure
CAS No.
113559-13-0
Chemical Name:
E-4031
Synonyms
E-4031;E4031 diHCl;E-4031 (hydrochloride);E-4031 dihydrochloride, HERG K+ channel blocker;1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined;methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb;Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG;N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride;N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid
CBNumber:
CB8384065
Molecular Formula:
C21H33Cl2N3O5S
Molecular Weight:
510.47
MOL File:
113559-13-0.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
Request For Quotation

E-4031 Properties

storage temp. -20°C
solubility H2O: soluble
form solid
color off-white
Water Solubility H2O: soluble
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
WGK Germany  3
NFPA 704
0
2 0

E-4031 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) M5060 E-4031 ≥98% (HPLC), lyophilized powder 113559-13-0 0.1MG ₹18597.35 2022-06-14 Buy
Sigma-Aldrich(India) M5060 E-4031 ≥98% (HPLC), lyophilized powder 113559-13-0 0.5MG ₹65263.93 2022-06-14 Buy
Sigma-Aldrich(India) M5060 E-4031 ≥98% (HPLC), lyophilized powder 113559-13-0 1MG ₹123448.3 2022-06-14 Buy
Product number Packaging Price Buy
M5060 0.1MG ₹18597.35 Buy
M5060 0.5MG ₹65263.93 Buy
M5060 1MG ₹123448.3 Buy

E-4031 Chemical Properties,Uses,Production

Uses

E-4031 has been used as:

  • human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
  • IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
  • IKr blocker in rat ventricular myocytes

Biological Activity

Selective blocker of hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.

Biochem/physiol Actions

E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.

E-4031 Preparation Products And Raw materials

Raw materials

Preparation Products

E-4031 Suppliers

Global( 95)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19552 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29808 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Alfa Chemistry United States 24072 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43340 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131957 58 Inquiry
Beijing Taize Jiaye Technology Development Co., Ltd. 400-800-8151 CHINA 6050 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
career henan chemical co 58
TargetMol Chemicals Inc. 58
Alfa Chemistry 58
TargetMol Chemicals Inc. 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Beijing Taize Jiaye Technology Development Co., Ltd. 58

113559-13-0(E-4031)Related Search:

N-Methylbenzylamine N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE 4-BENZOYLPIPERIDINE HYDROCHLORIDE Betahistine dihydrochloride N-(4-ACETYL-PHENYL)-METHANESULFON-AMIDE
E-4031,E-4031 DIHYDROCHLORIDE 4-(4-PIPERIDINYLMETHYL)-BENZENAMINE 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE E-4031
2-(2'-AMINOETHYL)-6-METHYLPYRIDINE RARECHEM AL F1 4031 AURORA KA-4031 RARECHEM AK PP 4031 AKOS BB-4031
AURORA 4031 E-4031, Voltage-Gated (HERG) K+ Channel Blocker, 510.48MW
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1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb E-4031 N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid E-4031 (hydrochloride) N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG E4031 diHCl Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-, hydrochloride (1:2) E-4031 dihydrochloride, HERG K+ channel blocker 113559-13-0 C21H27N3O3S2HCl Cell Biology Cell Signaling and Neuroscience Monovalent Ion Channels Ion Channels Potassium Channel Modulators Voltage-gated Ion Channels BioChemical Potassium channel Ion Channels