Betahistine dihydrochloride
- CAS No.
- 5579-84-0
- Chemical Name:
- Betahistine dihydrochloride
- Synonyms
- Betahistine Di HCl;BETAHISTINE HYDROCHLORIDE;PT-9;Serc;Betaserc;Microser;SinMenier;BetahistineHCl;Betahistine 2 hcl;Betahistine dihydroc
- CBNumber:
- CB8390055
- Molecular Formula:
- C8H14Cl2N2
- Molecular Weight:
- 209.12
- MOL File:
- 5579-84-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/28 7:28:55
| Melting point | 150-154 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Very soluble in water, soluble in ethanol (96 per cent), practically insoluble in 2propanol. |
| form | powder |
| color | Pale Yellow |
| Stability | Hygroscopic |
| InChI | InChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H |
| InChIKey | XVDFMHARQUBJRE-UHFFFAOYSA-N |
| SMILES | C1(CCNC)=NC=CC=C1.Cl.Cl |
| CAS DataBase Reference | 5579-84-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H413-H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UT2969000 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
Betahistine dihydrochloride price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2097 | Betahistine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 5579-84-0 | 500MG | ₹17947.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B4638 | Betahistine dihydrochloride ≥98% | 5579-84-0 | 5G | ₹7166.15 | 2022-06-14 | Buy |
Betahistine dihydrochloride Chemical Properties,Uses,Production
Description
Betahistine dihydrochloride (BH.2HCl) is an orally active histamine analog which has been used to control vertigo, lack of hearing and tinnitus related to Ménière’s disease. The mechanism of BH.2HCl is to reduce the pressure of the membranous labyrinth that results in enhancement of the microvasculature circulation and improves the signs of Ménière’s disease. Peroral administration undergoes extensive first-pass metabolism and gastric irritation in patients with peptic ulcer. In treatment of vertigo, a uniform and constant supply of drug is required in order to maintain steady-state concentration of the drug in the body. Unfortunately, BH.2HCl possesses a short half-life of about 3–4 h and requires frequent administration of the drug,12–15 thereby making it an ideal candidate for controlled release preparations.
Chemical Properties
white to light yellow crystalline powder
Uses
Betahistine is belongs to a group of medications used to treat vertigo associated with Ménière's disease. Vertigo is a condition that causes sufferers to have a sensation of rotation or movement of themselves or their surroundings. Ménière's disease is a disorder of the inner ear that causes vertigo in addition to symptoms such as ringing in the ears, headache, and loss of hearing.
Betahistine is used to reduce the number of episodes of vertigo associated with Ménière's disease. It is believed to work by decreasing the pressure in the ear. This pressure is believed to contribute to the sense of dizziness, nausea, and ringing in the ears and hearing loss that people with Ménière's disease experience.
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Side effects
Stomach upset, nausea, and headache may occur. This medication may also rarely cause drowsiness. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:
rash
itching/swelling (especially of the face/tongue/throat)
severe dizziness
trouble breathing
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Betahistine dihydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Enal Drugs Pvt Ltd | +914044753636 | Telangana, India | 35 | 58 | Inquiry |
| Venture Pharmaceuticals pvt ltd | +91-9173909075 +91-9173909075 | Gujarat, India | 45 | 58 | Inquiry |
| Integrin Life Sciences. Pvt. Ltd. | +91-4040265469 +91-9849990870 | Hyderabad, India | 90 | 58 | Inquiry |
| ZCL Chemicals Ltd | +91-2261539999 +91-2261539999 | Maharashtra, India | 53 | 58 | Inquiry |
| Humble Healthcare Limited | +91-9720093000 +91-8006400378 | Uttar Pradesh, India | 141 | 58 | Inquiry |
| Ami Lifesciences Pvt Ltd | +91-9426998100 +91-9426998100 | Gujarat, India | 62 | 58 | Inquiry |
| Cohance Lifesciences (Previously RA Chem Pharma Ltd) | +91-4044758595 +91-4044758595 | Telangana, India | 47 | 58 | Inquiry |
| Sibram Pharmaceutical | +91-8655777550 +91-8655777550 | Maharashtra, India | 244 | 58 | Inquiry |
| Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
| Bioxera Pharma Pvt. Ltd. | +91-2261842739 +91-2266862739 | Maharashtra, India | 20 | 58 | Inquiry |
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