Doxercalciferol
- CAS No.
- 54573-75-0
- Chemical Name:
- Doxercalciferol
- Synonyms
- C08211;TSA 840;1α-OHD2;Hectorol;ERCALCIDOL;1ALPHA-OH-D2;Doxecalciferol;Doxercalcifero;Doxercalciferol;Doxercalciferol d6
- CBNumber:
- CB8394169
- Molecular Formula:
- C28H44O2
- Molecular Weight:
- 412.65
- MOL File:
- 54573-75-0.mol
- Modify Date:
- 2023/9/20 16:43:00
| Melting point | 138-140°C |
|---|---|
| Boiling point | 538.7±50.0 °C(Predicted) |
| Density | 1.01±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: >10mg/mL |
| form | White crystalline solid |
| pka | 14.43±0.40(Predicted) |
| color | White to Almost white |
| InChIKey | HKXBNHCUPKIYDM-CGMHZMFXSA-N |
| SMILES | [C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@H](C)/C=C/[C@H](C)C(C)C)/C(=C)[C@@H](O)C1 |
| CAS DataBase Reference | 54573-75-0(CAS DataBase Reference) |
| EPA Substance Registry System | Doxercalciferol (54573-75-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P301+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28 | |||||||||
| Safety Statements | 28-36/37-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VS2950000 | |||||||||
| HS Code | 2936299055 | |||||||||
| Toxicity | LD50 orally in rats: 3.5-6.5 mg/kg (Sjden) | |||||||||
| NFPA 704 |
|
Doxercalciferol price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D0196 | Doxercalciferol ≥98% (HPLC), solubility: >10 mg/mL in DMSO | 54573-75-0 | 1MG | ₹12210.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D0196 | Doxercalciferol ≥98% (HPLC), solubility: >10 mg/mL in DMSO | 54573-75-0 | 5MG | ₹49069.73 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D5526 | Doxercalciferol | 54573-75-0 | 5MG | ₹4800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D5526 | Doxercalciferol | 54573-75-0 | 25MG | ₹10600 | 2022-05-26 | Buy |
Doxercalciferol Chemical Properties,Uses,Production
Description
Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha- D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in 5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile similar to calcitriol. During placebo-controlled clinical trials, patients with moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to 24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were considerably reduced, so maintaining a good control of the parathyroid hyperplasia. Moreover, only a moderate tendency to raise calcium and phosphate was observed. Doxercalciferol is orally-active and less toxic than other vitamin D analogs like alfacalcidol; it shows differentially controlled effects and has an improved safety profile compared to calcitriol.
Chemical Properties
Doxercalciferol is Crystalline Solid
Uses
Synthetic vitamin D prohormone. A new active Vitamin D analog which inhibits growth of human neuroblastoma. Antihyperparathyroid
Biological Activity
Vitamin D 2 analog that acts as a vitamin D receptor activator (VDRA).
Doxercalciferol Preparation Products And Raw materials
Raw materials
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Global( 233)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Sai Life Sciences Ltd | +91-4066777555 +91-8008555365 | Hyderabad, India | 24 | 58 | Inquiry |
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
54573-75-0(Doxercalciferol)Related Search:
1-alpha-hydroxyergocalciferol
1alpha-hydroxyergocalciferol
1-alpha-hydroxyvitamind2
1-hydroxyergocalciferol
1ALPHA-OH-D2
7,10(19),22-tetraene-1,3-diol,(1-alpha,3-beta,5z,7e,22e)-10-secoergosta-5
VITAMIN D2, 1ALPHA-HYDROXY-
Vitamin D2, 1a-Hydroxy-
(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Doxercalciferol
1A, 25-DIHYDROXYERGOCALCIFEROL
1A-HYDROXYERGOCALCIFEROL (NON GMP)
ERCALCIDOL
Doxecalciferol
4-Methylene-5-{2-[7a-methyl-1-(1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ylidene]-ethylidene}-cyclohexane-1,3-diol (1-alpha-Hydroxyvitamin D2)
(1a,3,5Z,7E,22E)- 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol1-Hydroxyergocalciferol
1a-Hydroxyergocalciferol
1a-Hydroxyvitamin D2
1-Hydroxy Vitamin D2
1-Hydroxyvitamin D2
Hectorol
TSA 840
(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyl-octahydroinden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
(5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1?,3?-diol
(5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1α,3β-diol
1α-OHD2
C08211
1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7α-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
(1S,3R,5Z,7E,22E)-9,10-Seco
4-methylene-5Z-[2E-[(1R,3aS)-octahydro-7aR-methyl-1R-[1R,4,5-trimethyl-2E-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3S-cyclohexanediol
(1R,3S,E)-5-((E)-2-((1R,3AS,7aR)-1-((2R,5S,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyldihydro-1H-
1-alpha-Hydroxy Vitamin D2-d6
Doxercalciferol d6
Doxercalciferol / Ercalcidol
Doxercalciferol CAS NO.54573-75-0 CAS NO.54573-75-0
Doxercalcifero
Vitamin D, 1α-Hydroxy- - CAS 54573-75-0 - Calbiochem
(1S,3R,5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
(5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
1α-Hydroxy Vitamin D2
Hydroxyergocalciferol
Doxercalciferol (1α-Hydroxyvitamin D2)
Doxercalciferol D6Q: What is
Doxercalciferol D6 Q: What is the CAS Number of
Doxercalciferol D6 Q: What is the storage condition of
Doxercalciferol D6 Q: What are the applications of
Doxercalciferol D6
DoxercalciferolQ: What is
Doxercalciferol Q: What is the CAS Number of
Doxercalciferol Q: What is the storage condition of
Doxercalciferol
Doxercalciferol (1225601)
(1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-Dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
54573-75-0
C28H44O2
Inhibitors
Vitamin D3 analogs
Chiral Reagents
Intermediates & Fine Chemicals
Pharmaceuticals
APIs
54573-75-0