Doxercalciferol
![Doxercalciferol Structure](CAS/GIF/54573-75-0.gif)
- CAS No.
- 54573-75-0
- Chemical Name:
- Doxercalciferol
- Synonyms
- C08211;TSA 840;1α-OHD2;Hectorol;ERCALCIDOL;1ALPHA-OH-D2;Doxecalciferol;Doxercalcifero;Doxercalciferol;Doxercalciferol d6
- CBNumber:
- CB8394169
- Molecular Formula:
- C28H44O2
- Molecular Weight:
- 412.65
- MOL File:
- 54573-75-0.mol
- Modify Date:
- 2023/9/20 16:43:00
Melting point | 138-140°C |
---|---|
Boiling point | 538.7±50.0 °C(Predicted) |
Density | 1.01±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO: >10mg/mL |
form | White crystalline solid |
pka | 14.43±0.40(Predicted) |
color | White to Almost white |
InChIKey | HKXBNHCUPKIYDM-CGMHZMFXSA-N |
SMILES | [C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@H](C)/C=C/[C@H](C)C(C)C)/C(=C)[C@@H](O)C1 |
CAS DataBase Reference | 54573-75-0(CAS DataBase Reference) |
EPA Substance Registry System | Doxercalciferol (54573-75-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H300 | |||||||||
Precautionary statements | P264-P301+P310 | |||||||||
Hazard Codes | T+ | |||||||||
Risk Statements | 28 | |||||||||
Safety Statements | 28-36/37-45 | |||||||||
RIDADR | UN 2811 6.1 / PGIII | |||||||||
WGK Germany | 3 | |||||||||
RTECS | VS2950000 | |||||||||
HS Code | 2936299055 | |||||||||
Toxicity | LD50 orally in rats: 3.5-6.5 mg/kg (Sjden) | |||||||||
NFPA 704 |
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Doxercalciferol price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | D0196 | Doxercalciferol ≥98% (HPLC), solubility: >10 mg/mL in DMSO | 54573-75-0 | 1MG | ₹12210.6 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | D0196 | Doxercalciferol ≥98% (HPLC), solubility: >10 mg/mL in DMSO | 54573-75-0 | 5MG | ₹49069.73 | 2022-06-14 | Buy |
TCI Chemicals (India) | D5526 | Doxercalciferol | 54573-75-0 | 5MG | ₹4800 | 2022-05-26 | Buy |
TCI Chemicals (India) | D5526 | Doxercalciferol | 54573-75-0 | 25MG | ₹10600 | 2022-05-26 | Buy |
Doxercalciferol Chemical Properties,Uses,Production
Description
Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha- D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in 5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile similar to calcitriol. During placebo-controlled clinical trials, patients with moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to 24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were considerably reduced, so maintaining a good control of the parathyroid hyperplasia. Moreover, only a moderate tendency to raise calcium and phosphate was observed. Doxercalciferol is orally-active and less toxic than other vitamin D analogs like alfacalcidol; it shows differentially controlled effects and has an improved safety profile compared to calcitriol.
Chemical Properties
Doxercalciferol is Crystalline Solid
Uses
Synthetic vitamin D prohormone. A new active Vitamin D analog which inhibits growth of human neuroblastoma. Antihyperparathyroid
Biological Activity
Vitamin D 2 analog that acts as a vitamin D receptor activator (VDRA).
Doxercalciferol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
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TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |