Mepivacaine
- CAS No.
- 22801-44-1
- Chemical Name:
- Mepivacaine
- Synonyms
- MEPIVACAINE;A pp because;MepivacaineBase;Mepivacaine USP/EP/BP;Mepivacaine Impurity A;Mepivacaine Impurity 1;Mepivacaine HCl (base);Mepivacaine hydorchloride;Trimethocaine hydrochloride;Mepivacaine(Cas number22801-44-1)
- CBNumber:
- CB8460318
- Molecular Formula:
- C15H22N2O
- Molecular Weight:
- 246.35
- MOL File:
- 22801-44-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/27 13:09:27
| Melting point | 147-151°C |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pKa 7.73(H2O,t =25±0.2,I=0.01(NaCl)) (Uncertain) |
| color | White to Off-White |
| InChI | InChI=1S/C15H22N2O/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18) |
| InChIKey | INWLQCZOYSRPNW-UHFFFAOYSA-N |
| SMILES | N1(C)CCCCC1C(NC1=C(C)C=CC=C1C)=O |
| CAS DataBase Reference | 22801-44-1(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl- (22801-44-1) |
Mepivacaine Chemical Properties,Uses,Production
Uses
Local anesthetic.
General Description
Mepivacaine hydrochloride is available in 1% to 3% solutionsand is indicated for infiltration anesthesia, dental procedures,peripheral nerve block, or epidural block. The onset of anesthesiais rapid, ranging from about 3 to 20 minutes for sensoryblock. Mepivacaine is rapidly metabolized in the liver with50% of the administered dose excreted into the bile asmetabolites. The metabolites are reabsorbed in the intestineand excreted in the kidney with only a small percentage foundin the feces. Less than 5% to 10% of the administered dose isfound unchanged in the urine. The primary metabolic productsare the N-demethylated metabolite and the 3 and 4 phenolicmetabolites excreted as their glucuronide conjugates.
Clinical Use
Mepivacaine hydrochloride [N-(2, 6-dimethylphenyl)-1-methyl 2-piperidinecarboxamide monohydrochloride] is an amino amide-type local anesthetic agent widely used to provide regional analgesia and anesthesia by local infiltration, peripheral nerve block, and epidural and caudal blocks. The pharmacological and toxicological profile of mepivacaine is quite similar to that of lidocaine, except that mepivacaine has a slightly longer duration of action and lacks the vasodilator activity of lidocaine. For this reason, it serves as an alternate choice for lidocaine when addition of epinephrine is not recommended in patients with hypertensive vascular disease.
Metabolism
Mepivacaine undergoes extensive hepatic metabolism catalyzed by CYP1A2, with only a small percentage of the administered dosage (<10%) being excreted unchanged in the urine. The major metabolic biotransformations of mepivacaine are N-dealkylation (to give the N-demethylated compound 2′,6′-pipecoloxylidide) and aromatic hydroxylations. These metabolites are excreted as their corresponding glucuronides.
Mepivacaine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Akshar Homoeo Pharmacy | 08048372804Ext 868 | Gujarat, India | 6 | 58 | Inquiry |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | China | 289 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | China | 436 | 58 | Inquiry |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | China | 2118 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Sigma Audley | +86-15937194204 +86-18126314766 | China | 491 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
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