Articaine
- CAS No.
- 23964-58-1
- Chemical Name:
- Articaine
- Synonyms
- 40045;Articain;ARTICAINE;Articaina;Articainum;Carticaine;ARTICAINE HCL;Unii-D3sq406G9x;Articaine (USP);Articaine (40 mg)
- CBNumber:
- CB9115297
- Molecular Formula:
- C13H20N2O3S
- Molecular Weight:
- 284.37
- MOL File:
- 23964-58-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/19 22:55:17
| Melting point | 175-176 °C |
|---|---|
| Boiling point | bp0.3 162-167° |
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 13.46±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16) |
| InChIKey | QTGIAADRBBLJGA-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)SC=C(C)C=1NC(=O)C(NCCC)C |
| CAS DataBase Reference | 23964-58-1(CAS DataBase Reference) |
Articaine Chemical Properties,Uses,Production
Description
Articaine [4-methyl-3-(2-propylaminopropionamido) thiophene-2-carboxylic acid methyl ester
hydrochloride] has been widely used in dentistry since its approval by the U.S. FDA in the year
2000 because of its quick onset and short duration of action. The structure of articaine differs
from those of all other amino amide-type local anesthetics in that it contains a thiophene ring
instead of a benzene ring and a carbomethoxy group. This renders the molecule more lipophilic
and, thus, easier to cross any lipoidal membranes.
Its local anesthetic potency is approximately 1.5-fold that of lidocaine, even though it has similar
pKa (7.8) and plasma protein binding (76%) properties. Articaine also is metabolized primarily by
plasma cholinesterases because of the presence of an ester group and, therefore, has a much
shorter duration of action than lidocaine (i.e., only approximately one-fourth that of lidocaine).
Articaine undergoes rapid hydrolysis of the carbomethoxy group to give articainic acid, which is
eliminated either unchanged (75%) or as its glucuronides (25%). Compared with to other shortacting, amino amide-type local anesthetics, such as mepivacaine, lidocaine, or prilocaine,
articaine is said to be a much safer drug for regional anesthesia and is the drug of choice for
dental procedures.
Uses
Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand , food surgery and in dentistry.
Contact allergens
This local amide-type anesthetic is seldom reported as allergenic even in patients sensitized to other amidetype molecules like lidocaine, prilocaine, mepivacaine, or bupivacaine.
Articaine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Val Organics Pvt Ltd | +91-2224106455 +91-2224106455 | Maharashtra, India | 35 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Apex Healthcare Limited | +9199825711244 | Gujarat, India | 22 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | China | 305 | 58 | Inquiry |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | China | 299 | 58 | Inquiry |
Related articles
- Articaine: Pharmacology, Efficacy and Safety
- Articaine, an amide local anesthetic with a thiophene ring, offers enhanced potency and lipid solubility. Rapid metabolism by ....
- Apr 10，2024
- What is Articaine?
- Articaine (Septocaine) 1:100,000 epinephrine was approved for use in the United States in 2000.
- Nov 13，2023
23964-58-1(Articaine)Related Search:
1of4
chevron_right