NVP-AAM077
- CAS No.
- 459836-30-7
- Chemical Name:
- NVP-AAM077
- Synonyms
- PEAQX;CS-1513;AAM 007;NVP-AAM077;PEAQX sodium;NVP-AAM077Na;PEAQX(NVP-AAM 077);NVP-AAM077 sodium salt;PEAQX,Inhibitor,Ionotropic glutamate receptors,inhibit,iGluR;NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem
- CBNumber:
- CB8497088
- Molecular Formula:
- C17H17BrN3O5P
- Molecular Weight:
- 454.21
- MOL File:
- 459836-30-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 15:51:00
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
NVP-AAM077 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P1999 | PEAQX tetrasodium hydrate ≥98% (HPLC) | 459836-30-7 | 5MG | ₹17536.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P1999 | PEAQX tetrasodium hydrate ≥98% (HPLC) | 459836-30-7 | 25MG | ₹68533.08 | 2022-06-14 | Buy |
| Sigma-Aldrich | 5.04528 | NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem | 459836-30-7 | 5MG | ₹21209.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.04528 | NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem | 459836-30-7 | 5MG | ₹21209.99 | 2022-06-14 | Buy |
NVP-AAM077 Chemical Properties,Uses,Production
Uses
PEAQX tetrasodium hydrate has been used N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) antagonist in rats and mice.
Biochem/physiol Actions
PEAQX is more specific for N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) than N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) and induces striatal apoptosis. It is less potent in activating caspase-3 than its stereomer NVP-AAM007.
Enzyme inhibitor
This potent NMDA receptor antagonist and experimental anticonvulsant (FW = 542.14 g/mol), also known as NVP-AAM077 and tetrasodium [[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5- quinoxalinyl)methyl] phosphonate, is a competitive antagonist for ionotropic glutamate [N-methyl-D-aspartate] receptors (or GluN receptors). Although originally described as being 100x more active against GluN1/GluN2A receptors versus GluN1/GluN2B receptors, later studies revealed only a 5x difference in affinity. There is no difference in the steady-state levels of inhibition produced by NVP-AAM077 when it was either preapplied or coapplied with glutamate.
NVP-AAM077 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | China | 3136 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9707 | 58 | Inquiry |
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